Cubs vs Red Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 27

Odds updated as of 5:12 a.m.

The Chicago Cubs are among the MLB teams in action on Sunday, versus the Boston Red Sox.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Cubs vs Red Sox Game Info

• Chicago Cubs (88-73) vs. Boston Red Sox (87-74)
• Date: Sunday, September 27, 2026
• Time: 3:05 p.m. ET
• Venue: Tropicana Field -- St. Petersburg, Florida
• Coverage: NESN and MARQ

Cubs vs Red Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-124) | BOS: (+106)
• Spread: CHC: -1.5 (+138) | BOS: +1.5 (-166)
• Total: 7.5 -- Over: (-105) | Under: (-115)

Cubs vs Red Sox Probable Starting Pitchers

Probable Pitchers: TBA (Cubs) vs TBA (Red Sox)

As of this writing, neither squad has named a starting pitcher for this matchup.

Cubs vs Red Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (55.8%)

Cubs vs Red Sox Moneyline

• The moneyline numbers for Cubs vs. Red Sox reveal Chicago as the favorite (-124) and Boston as the underdog (+106) despite being the home team.

Cubs vs Red Sox Spread

• The Red Sox are at +1.5 on the runline against the Cubs. The Red Sox are -166 to cover the spread, and the Cubs are +138.

Cubs vs Red Sox Over/Under

• An over/under of 7.5 has been set for Cubs-Red Sox on Sept. 27, with the over being -105 and the under -115.

Bet on Chicago Cubs vs. Boston Red Sox on FanDuel today!

Cubs vs Red Sox Betting Trends

• The Cubs have been chosen as favorites in 108 games this year and have walked away with the win 60 times (55.6%) in those games.
• This season Chicago has been victorious 48 times in 88 chances when named as a favorite of at least -124 on the moneyline.
• The Cubs' games have gone over the total in 88 of their 156 opportunities.
• In 156 games with a line this season, the Cubs have a mark of 73-83-0 against the spread.
• The Red Sox have won 50% of the games this season they were the moneyline underdog (23-23).
• In games it has played as a moneyline underdog with odds of +106 or longer, Boston has a record of 12-18 (40%).
• The Red Sox have combined with opponents to go over the total 69 times this season for a 69-87-2 record against the over/under.
• The Red Sox have covered 47.5% of their games this season, going 75-83-0 ATS.

Cubs Player Leaders

• Pete Crow-Armstrong leads Chicago with 174 hits and an OBP of .372, plus a team-best slugging percentage of .570. He's batting .278.
• Among qualified hitters, he is 28th in batting average, his on-base percentage ranks 13th, and he is second in slugging.
• Alex Bregman is hitting .260 with 32 doubles, two triples, 26 home runs and 75 walks, while slugging .449 with an on-base percentage of .350.
• He ranks 64th in batting average, 42nd in on-base percentage and 47th in slugging among qualifying hitters.
• Seiya Suzuki has 147 hits this season and has a slash line of .270/.368/.473.
• Nico Hoerner has eight home runs, 72 RBI and a batting average of .264 this season.

Red Sox Player Leaders

• Wilyer Abreu has 38 doubles, four triples, 24 home runs and 70 walks while hitting .249. He's slugging .448 with an on-base percentage of .328.
• He ranks 80th in batting average, 76th in on-base percentage and 49th in slugging percentage among all qualified hitters in the majors.
• Caleb Durbin is hitting .248 with 25 doubles, a triple, 13 home runs and 51 walks. He's slugging .379 with an on-base percentage of .333.
• Including all qualified hitters, his batting average places him 84th, his on-base percentage is 62nd, and he is 110th in slugging.
• Willson Contreras has racked up 123 hits with a .387 on-base percentage, leading the Red Sox in both categories.
• Ceddanne Rafaela's .442 slugging percentage paces his team.

Cubs vs Red Sox Head to Head

• 9/25/2026: 2-0 BOS (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 9/25/2026: 4-3 BOS (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/20/2025: 6-1 BOS (Favorite: Red Sox, Spread: -1.5, Total: 7, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 7/19/2025: 6-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 7/18/2025: 4-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 4/28/2024: 5-4 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 4/27/2024: 17-0 BOS (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/26/2024: 7-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/16/2023: 11-5 BOS (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 7/15/2023: 10-4 CHC (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -116, Underdog Moneyline: -102)

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