Cubs vs Rays Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 12

Odds updated as of 12:11 a.m.

The Chicago Cubs versus the Tampa Bay Rays is on the MLB schedule for Friday.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information about this matchup.

Cubs vs Rays Game Info

• Chicago Cubs (83-63) vs. Tampa Bay Rays (72-74)
• Date: Friday, September 12, 2025
• Time: 2:20 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: MLB Network, MARQ, and FDSSUN

Cubs vs Rays Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-172) | TB: (+144)
• Spread: CHC: -1.5 (+126) | TB: +1.5 (-152)
• Total: 7.5 -- Over: (-100) | Under: (-122)

Cubs vs Rays Probable Starting Pitchers

Probable Pitchers: Matthew Boyd (Cubs) - 12-8, 2.92 ERA vs Shane Baz (Rays) - 9-11, 4.94 ERA

This contest's pitching matchup is set, as the Cubs will send Matthew Boyd (12-8) to the mound, while Shane Baz (9-11) will get the nod for the Rays. Boyd's team is 10-17-0 against the spread in his starts this season. Boyd's team is 11-10 this season when he starts and they are the moneyline favorite. The Rays are 12-15-0 against the spread when Baz starts. The Rays have a 5-6 record in Baz's 11 starts this season when they were the underdog on the moneyline.

Cubs vs Rays Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (56.3%)

Cubs vs Rays Moneyline

• Chicago is the favorite, -172 on the moneyline, while Tampa Bay is a +144 underdog on the road.

Cubs vs Rays Spread

• The Rays are at +1.5 on the runline against the Cubs. The Rays are -152 to cover the spread, and the Cubs are +126.

Cubs vs Rays Over/Under

• Cubs versus Rays, on Sept. 12, has an over/under of 7.5, with the over being -100 and the under -122.

Bet on Chicago Cubs vs. Tampa Bay Rays on FanDuel today!

Cubs vs Rays Betting Trends

• The Cubs have come away with 62 wins in the 99 contests they have been listed as the favorites in this season.
• Chicago has a record of 23-12 in contests when sportsbooks favor them by -172 or more on the moneyline.
• The Cubs and their opponents have gone over in 65 of their 142 games with a total set by sportsbooks this season.
• The Cubs are 65-77-0 against the spread in their 142 games that had a posted line this season.
• The Rays have been the moneyline underdog 67 total times this season. They've gone 28-39 in those games.
• Tampa Bay has gone 3-6 in games it has played as a moneyline underdog with odds of +144 or longer (33.3%).
• The Rays have had an over/under set by oddsmakers 141 times, and have combined with opponents to go over the total in 61 of those games (61-73-7).
• The Rays are 61-80-0 against the spread this season.

Cubs Player Leaders

• Pete Crow-Armstrong leads Chicago in total hits (134) this season while batting .251 with 67 extra-base hits. He has an on-base percentage of .294 and a slugging percentage of .490.
• He is 92nd in batting average, 134th in on-base percentage, and 24th in slugging among qualifying hitters in the majors.
• Nico Hoerner leads Chicago in slugging percentage (.390) thanks to 36 extra-base hits. He's batting .294 with an on-base percentage of .343.
• He is eighth in batting average, 47th in on-base percentage and 115th in slugging in the majors.
• Hoerner takes a six-game streak with at least one hit into this contest. During his last 10 outings he is batting .317 with four doubles, a home run, three walks and three RBIs.
• Seiya Suzuki is batting .244 with a .461 slugging percentage and 91 RBI this year.
• Suzuki brings a six-game hitting streak into this game. In his last 10 games he is hitting .211 with a double, six walks and four RBIs.
• Ian Happ is batting .237 with a .338 OBP and 66 RBI for Chicago this season.
• Happ enters this game on a two-game hitting streak. During his last five outings he is batting .190 with a double and two walks.

Rays Player Leaders

• Junior Caminero has 144 hits, a team-best for the Rays. He's batting .261 and slugging .538 with an on-base percentage of .300.
• He ranks 71st in batting average, 124th in on-base percentage and 11th in slugging percentage among all qualifying batters in MLB.
• Yandy Diaz paces his team with a .350 on-base percentage, and has a club-best .474 slugging percentage. He has a batting average of .292.
• Including all qualified players, he ranks 11th in batting average, 37th in on-base percentage and 35th in slugging percentage.
• Brandon Lowe is hitting .260 with 17 doubles, 28 home runs and 36 walks.
• Chandler Simpson is hitting .292 with 11 doubles, three triples and 18 walks.

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