Cubs vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 12

Odds updated as of 10:12 p.m.

The Saturday schedule in MLB includes a matchup between the Chicago Cubs and the Pittsburgh Pirates.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information regarding this game.

Cubs vs Pirates Game Info

• Chicago Cubs (82-66) vs. Pittsburgh Pirates (74-74)
• Date: Saturday, September 12, 2026
• Time: 2:20 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: MARQ and SportsNet PT

Cubs vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-122) | PIT: (+104)
• Spread: CHC: -1.5 (+155) | PIT: +1.5 (-188)
• Total: 8.5 -- Over: (-134) | Under: (+110)

Cubs vs Pirates Probable Starting Pitchers

Probable Pitchers: Clay Holmes (Cubs) - 6-7, 2.83 ERA vs Paul Skenes (Pirates) - 10-11, 3.83 ERA

This contest's pitching matchup is set, as the Cubs will send Clay Holmes (6-7) to the mound, while Paul Skenes (10-11) will get the nod for the Pirates. Holmes and his team have a record of 6-9-0 against the spread when he starts. Holmes' team has been victorious in 50% of the games he's started as the moneyline favorite with a record of 5-5. The Pirates have a 9-20-0 ATS record in Skenes' 29 starts that had a set spread. The Pirates have a 2-3 record in Skenes' five starts this season when they were the moneyline underdog.

Cubs vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (53%)

Cubs vs Pirates Moneyline

• The moneyline numbers for Cubs vs. Pirates reveal Chicago as the favorite (-122) and Pittsburgh as the underdog (+104) on the road.

Cubs vs Pirates Spread

• The Pirates are +1.5 on the spread (-188 to cover), and Chicago is +155 to cover the runline.

Cubs vs Pirates Over/Under

• Cubs versus Pirates on Sept. 12 has an over/under of 8.5 runs, with the odds on the over -134 and the under set at +110.

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Cubs vs Pirates Betting Trends

• The Cubs have been victorious in 54, or 56.8%, of the 95 contests they have been chosen as favorites in this season.
• This season Chicago has been victorious 42 times in 77 chances when named as a favorite of at least -122 on the moneyline.
• The Cubs' games have gone over the total in 80 of their 143 opportunities.
• The Cubs are 69-74-0 against the spread in their 143 games with a line set by sportsbooks this season.
• The Pirates have a 30-38 record in games they were the underdog on the moneyline (winning 44.1% of those games).
• Pittsburgh has a 20-27 record (winning 42.6% of its games) when playing as a moneyline underdog of +104 or longer.
• The Pirates have had an over/under set by bookmakers 146 times, and have combined with opponents to go over the total in 76 of those games (76-66-4).
• The Pirates have a 70-76-0 record ATS this season.

Cubs Player Leaders

• Pete Crow-Armstrong leads Chicago with 160 hits and an OBP of .376, plus a team-best slugging percentage of .570. He's batting .281.
• Among qualifying hitters in the majors, his batting average ranks 23rd, his on-base percentage ranks ninth, and he is second in slugging.
• Crow-Armstrong has recorded a base hit in nine straight games. In his last 10 games he is batting .263 with a double, three home runs, six walks and seven RBIs.
• Alex Bregman is hitting .263 with 30 doubles, a triple, 25 home runs and 71 walks. He's slugging .449 with an on-base percentage of .351.
• Among qualifying batters, he ranks 56th in batting average, 38th in on-base percentage and 47th in slugging percentage.
• Bregman brings a two-game streak with at least one hit into this one. In his last five games he is hitting .353 with two doubles, a home run, three walks and three RBIs.
• Seiya Suzuki has collected 134 base hits, an OBP of .369 and a slugging percentage of .480 this season.
• Nico Hoerner has eight home runs, 66 RBI and a batting average of .267 this season.
• Hoerner enters this game on a three-game hitting streak. During his last five outings he is hitting .286 with a double and two RBIs.

Pirates Player Leaders

• Bryan Reynolds a has .370 on-base percentage to lead the Pirates. He's batting .265 while slugging .431.
• Including all the qualifying hitters in the big leagues, his batting average places him 52nd, his on-base percentage is 15th, and he is 59th in slugging.
• Brandon Lowe's 138 hits lead his team. He has a batting average of .257 while slugging .476 with an on-base percentage of .326.
• Including all qualified hitters, he is 66th in batting average, 72nd in on-base percentage and 27th in slugging percentage.
• Nick Gonzales has put up a slugging percentage of .392, a team-high for the Pirates.
• Ryan O'Hearn is hitting .269 with 15 doubles, 17 home runs and 31 walks.

Cubs vs Pirates Head to Head

• 9/11/2026: 12-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 7/26/2026: 8-7 PIT (Favorite: Pirates, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/25/2026: 11-0 CHC (Favorite: Pirates, Spread: -1.5, Total: 8, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/24/2026: 3-2 CHC (Favorite: Pirates, Spread: -1.5, Total: 8, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 5/28/2026: 7-2 CHC (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 5/27/2026: 10-4 CHC (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/26/2026: 12-1 PIT (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 5/25/2026: 2-1 PIT (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/12/2026: 7-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 12.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 4/11/2026: 4-3 PIT (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -144, Underdog Moneyline: +122)

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