Cubs vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for April 10

Odds updated as of 2:11 p.m.

The MLB's Friday slate includes the Chicago Cubs taking on the Pittsburgh Pirates.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital info regarding this game.

Cubs vs Pirates Game Info

• Chicago Cubs (6-6) vs. Pittsburgh Pirates (7-5)
• Date: Friday, April 10, 2026
• Time: 2:20 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: MARQ and SportsNet PT

Cubs vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-152) | PIT: (+128)
• Spread: CHC: -1.5 (+146) | PIT: +1.5 (-176)
• Total: 6.5 -- Over: (-122) | Under: (+100)

Cubs vs Pirates Probable Starting Pitchers

Probable Pitchers: Shota Imanaga (Cubs) - 0-1, 4.50 ERA vs Carmen Mlodzinski (Pirates) - 0-0, 4.00 ERA

The probable starters are Shota Imanaga (0-1) for the Cubs and Carmen Mlodzinski for the Pirates. Imanaga has a record of 0-2-0 ATS in two starts with a spread this season. Imanaga's team is 0-2 this season when he starts and they're favored on the moneyline. Mlodzinski has started two games with set spreads, and the Pirates covered in both chances. The Pirates were the underdog on the moneyline for one Mlodzinski start this season -- they won.

Cubs vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (54.3%)

Cubs vs Pirates Moneyline

• Pittsburgh is the underdog, +128 on the moneyline, while Chicago is a -152 favorite at home.

Cubs vs Pirates Spread

• The Pirates are +1.5 on the spread (-176 to cover), and Chicago is +146 to cover the runline.

Cubs vs Pirates Over/Under

• Cubs versus Pirates on April 10 has an over/under of 6.5 runs, with the odds on the over -122 and the under set at +100.

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Cubs vs Pirates Betting Trends

• The Cubs have been victorious in four of the nine contests they have been chosen as favorites in this season.
• Chicago has a record of 3-2 when favored by -152 or more this year.
• The Cubs' games have gone over the total in six of their 12 opportunities.
• The Cubs have posted a record of 5-7-0 against the spread this season.
• The Pirates have won 33.3% of the games this season they were the moneyline underdog (2-4).
• Pittsburgh has played as a moneyline underdog of +128 or longer in just two games this season, which it split 1-1.
• The Pirates have played in 12 games with an over/under set, and have combined with opponents to go over the total seven times (7-5-0).
• The Pirates have covered 58.3% of their games this season, going 7-5-0 against the spread.

Cubs Player Leaders

• Nico Hoerner leads Chicago OPS (1.000) this season. He has a .333 batting average, an on-base percentage of .453, and a slugging percentage of .548.
• Among all qualified hitters in baseball, he is 13th in batting average, eighth in on-base percentage, and 28th in slugging.
• Hoerner will look for his fifth straight game with a hit in this contest. During his last five outings he is batting .389 with two doubles, a home run, three walks and six RBIs.
• Ian Happ has eight hits, which is tops among Chicago batters this season. He's batting .200 with six extra-base hits. He's also slugging .550 with an on-base percentage of .289.
• Among qualified hitters, his batting average ranks him 129th, his on-base percentage 126th, and his slugging percentage 27th.
• Happ brings a two-game streak with at least one hit into this contest. During his last five outings he is batting .190 with two doubles, a home run, a walk and two RBIs.
• Matt Shaw is batting .257 with a .457 slugging percentage and six RBI this year.
• Shaw enters this game with four games in a row with at least one hit. During his last five outings he is hitting .294 with a double, two home runs, two walks and three RBIs.
• Alex Bregman is batting .188 with a .278 OBP and three RBI for Chicago this season.

Pirates Player Leaders

• Ryan O'Hearn has racked up 14 hits with a .449 on-base percentage and a .625 slugging percentage, all club-highs for the Pirates. He's batting .350.
• Including all qualifying players in the big leagues, he is ninth in batting average, 10th in on-base percentage and 12th in slugging percentage.
• Oneil Cruz is slugging .583 to lead his team. He has a batting average of .292 with an on-base percentage of .333.
• His batting average is 39th among all qualified players, his on-base percentage ranks 76th, and he is 16th in slugging.
• Bryan Reynolds is batting .244 with a double, two home runs and eight walks.
• Brandon Lowe has two doubles, three home runs and seven walks while hitting .220.

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