Cubs vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for July 27

Odds updated as of 4:12 a.m.

The MLB schedule on Monday includes the Chicago Cubs facing the St. Louis Cardinals.

All the information you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Cubs vs Cardinals Game Info

• Chicago Cubs (59-46) vs. St. Louis Cardinals (53-52)
• Date: Monday, July 27, 2026
• Time: 7:45 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: Cardinals.TV and MARQ

Cubs vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-110) | STL: (-106)
• Spread: CHC: -1.5 (+134) | STL: +1.5 (-162)
• Total: 9.5 -- Over: (-110) | Under: (-110)

Cubs vs Cardinals Probable Starting Pitchers

Probable Pitchers: David Peterson (Cubs) - 5-7, 5.97 ERA vs Matthew Liberatore (Cardinals) - 5-7, 5.18 ERA

The probable starters are David Peterson (5-7) for the Cubs and Matthew Liberatore (5-7) for the Cardinals. Peterson's team is 4-8-0 against the spread this season in his starts. Peterson's team has a record of 3-4 this season when he starts and they are the favorite on the moneyline. The Cardinals have gone 10-10-0 against the spread when Liberatore starts. The Cardinals are 7-7 in Liberatore's 14 starts this season that they were the underdog on the moneyline.

Cubs vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (59.7%)

Cubs vs Cardinals Moneyline

• St. Louis is the underdog, -106 on the moneyline, while Chicago is a -110 favorite despite being on the road.

Cubs vs Cardinals Spread

• The Cardinals are +1.5 on the run line against the Cubs. The Cardinals are -162 to cover, and the Cubs are +134.

Cubs vs Cardinals Over/Under

• The over/under for Cubs-Cardinals on July 27 is 9.5. The over is -110, and the under is -110.

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Cubs vs Cardinals Betting Trends

• The Cubs have been chosen as favorites in 67 games this year and have walked away with the win 38 times (56.7%) in those games.
• This season Chicago has been victorious 38 times in 67 chances when named as a favorite of at least -110 on the moneyline.
• The Cubs and their opponents have gone over in 55 of their 101 games with a total set by sportsbooks this season.
• In 101 games with a line this season, the Cubs have a mark of 46-55-0 against the spread.
• The Cardinals have won 47.9% of the games this season they were the moneyline underdog (34-37).
• St. Louis has a 34-36 record (winning 48.6% of its games) when it has played as a moneyline underdog of -106 or longer.
• The Cardinals have had an over/under set by oddsmakers 103 times, and have combined with opponents to go over the total in 41 of those games (41-56-6).
• The Cardinals have a 57-46-0 record against the spread this season.

Cubs Player Leaders

• Pete Crow-Armstrong leads Chicago in OBP (.388), slugging percentage (.545) and total hits (114) this season. He has a .290 batting average.
• Among qualified batters in the majors, he ranks 15th in batting average, sixth in on-base percentage, and ninth in slugging.
• Crow-Armstrong hopes to build on a three-game hitting streak in this matchup. During his last five outings he is batting .474 with three doubles, two triples, two home runs, four walks and seven RBIs.
• Nico Hoerner is hitting .247 with 23 doubles, a triple, four home runs and 36 walks. He's slugging .337 with an on-base percentage of .312.
• Among qualified hitters, he ranks 90th in batting average, 105th in on-base percentage and 142nd in slugging percentage.
• Hoerner has picked up at least one hit in three games in a row. During his last five outings he is hitting .238 with an RBI.
• Dansby Swanson has 76 hits this season and has a slash line of .220/.299/.413.
• Swanson heads into this matchup with three games in a row with at least one hit. In his last five games he is hitting .389 with a double, two walks and three RBIs.
• Michael Busch is batting .247 with a .368 OBP and 56 RBI for Chicago this season.
• Busch heads into this game on a two-game hitting streak. In his last five games he is hitting .292 with a double, a walk and three RBIs.

Cardinals Player Leaders

• Jordan Walker leads the Cardinals with 114 hits. He's batting .286 and slugging .510 with an on-base percentage of .346.
• Including all qualifying hitters in MLB, he is 21st in batting average, 54th in on-base percentage and 16th in slugging percentage.
• Alec Burleson's .471 slugging percentage paces his team. He has a batting average of .289 with an on-base percentage of .348.
• Including all qualifying players, he is 16th in batting average, 50th in on-base percentage and 37th in slugging percentage.
• JJ Wetherholt is hitting .253 with 10 doubles, 15 home runs and 45 walks.
• Ivan Herrera leads his team with a .366 on-base percentage.

Cubs vs Cardinals Head to Head

• 7/5/2026: 6-4 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 7/3/2026: 17-1 STL (Favorite: Cubs, Spread: -1.5, Total: 10.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/31/2026: 5-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 5/30/2026: 6-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/29/2026: 6-5 STL (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/28/2025: 2-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 9/27/2025: 7-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 9/26/2025: 12-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -180, Underdog Moneyline: +152)
• 8/9/2025: 9-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 8/8/2025: 5-0 STL (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -166, Underdog Moneyline: +140)

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