Cubs vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for May 23

Odds updated as of 9:12 p.m.

MLB action on Saturday includes the Chicago Cubs taking on the Houston Astros.

We've got you covered, in terms of the vital info about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Cubs vs Astros Game Info

• Chicago Cubs (29-22) vs. Houston Astros (21-31)
• Date: Saturday, May 23, 2026
• Time: 2:20 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: MARQ and SCHN

Cubs vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-142) | HOU: (+120)
• Spread: CHC: -1.5 (+158) | HOU: +1.5 (-192)
• Total: 7.5 -- Over: (-105) | Under: (-115)

Cubs vs Astros Probable Starting Pitchers

Probable Pitchers: Colin Rea (Cubs) - 4-2, 4.98 ERA vs Kai-Wei Teng (Astros) - 2-3, 2.61 ERA

The Cubs will call on Colin Rea (4-2) versus the Astros and Kai-Wei Teng (2-3). Rea and his team have a record of 2-5-0 against the spread when he starts. When Rea starts a game and his team is the favorite on the moneyline, they have a record of 3-1. The Astros have a 1-2-0 ATS record in Teng's three starts with a set spread. The Astros have been the underdog on the moneyline in three of Teng's starts this season, and they went 1-2 in those games.

Cubs vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (54.7%)

Cubs vs Astros Moneyline

• Looking at the moneyline for Astros-Cubs, Houston is the underdog at +120, and Chicago is -142 playing at home.

Cubs vs Astros Spread

• The Cubs are favored by 1.5 runs at home versus the Astros. The Cubs are +158 to cover the spread, while the Astros are -192.

Cubs vs Astros Over/Under

• Cubs versus Astros, on May 23, has an over/under of 7.5, with the over being -105 and the under -115.

Bet on Chicago Cubs vs. Houston Astros on FanDuel today!

Cubs vs Astros Betting Trends

• The Cubs have been victorious in 20, or 60.6%, of the 33 contests they have been chosen as favorites in this season.
• This year Chicago has won 12 of 19 games when listed as at least -142 on the moneyline.
• The Cubs' games have gone over the total in 28 of their 50 opportunities.
• The Cubs have an against the spread mark of 21-29-0 in 50 games with a line this season.
• The Astros have won 42.9% of the games this season they were the underdog on the moneyline (15-20).
• Houston has a 5-12 record (winning just 29.4% of its games) when it has played as a moneyline underdog of +120 or longer.
• The Astros have had an over/under set by bookmakers 52 times, and have combined with opponents to go over the total in 28 of those games (28-22-2).
• The Astros have put together a 21-31-0 record against the spread this season (covering 40.4% of the time).

Cubs Player Leaders

• Nico Hoerner has an OPS of .728, fueled by an OBP of .345 and a team-best slugging percentage of .383 this season. He has a .259 batting average.
• Among qualified batters, he is 72nd in batting average, his on-base percentage ranks 64th, and he is 102nd in slugging.
• Michael Busch has 41 hits this season and a team-best OBP of .361. He's batting .229 and slugging .369.
• Among qualified batters, his batting average ranks him 120th, his on-base percentage 38th, and his slugging percentage 121st.
• Dansby Swanson has 31 hits this season and has a slash line of .187/.289/.349.
• Ian Happ has been key for Chicago with 39 hits, an OBP of .350 plus a slugging percentage of .429.

Astros Player Leaders

• Yordan Alvarez has racked up 57 hits with a .416 on-base percentage and a .601 slugging percentage, all club-bests for the Astros. He's batting .303.
• Including all qualified players in the majors, he ranks 12th in batting average, third in on-base percentage and fourth in slugging percentage.
• Christian Walker is hitting .254 with 10 doubles, 11 home runs and 18 walks. He's slugging .481 with an on-base percentage of .327.
• He is 81st in batting average, 84th in on-base percentage and 37th in slugging percentage in the big leagues.
• Isaac Paredes is hitting .244 with seven doubles, five home runs and 17 walks.
• Cam Smith is hitting .207 with six doubles, four home runs and 19 walks.

Cubs vs Astros Head to Head

• 5/22/2026: 4-2 HOU (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 6/29/2025: 2-0 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 6/28/2025: 12-3 CHC (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/27/2025: 7-4 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/25/2024: 3-1 CHC (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 4/24/2024: 4-3 CHC (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/23/2024: 7-2 CHC (Favorite: Astros, Spread: -1.5, Total: 10, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/17/2023: 7-6 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 5/16/2023: 7-3 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 5/15/2023: 6-4 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -196, Underdog Moneyline: +164)

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