College Football Predictions - 3 Best Spread Picks and 3 Best Over/Under Bets Today

CFB Early Slate Best Bets in Summary

• Ohio State -3.5
• James Madison -10.5
• Duke -3.5
• Over 63.5 (Cincinnati vs West Virginia)
• Under 42.5 (UMass vs Buffalo)
• Over 43.5 (Western Michigan vs Central Michigan)

Saturday's early college football slate is loaded, and a look at how the market has priced each line turns up a real, genuinely rare trend — three favorites are actually priced at plus money, a clear signal of where the value sits. Here are the three best spread picks and three best over/under bets for the early window.

All college football odds come from FanDuel Sportsbook's college football betting odds and may change after this article is published.

Best Spread Picks for Saturday's Early Slate

Ohio State at Indiana (Sat, 12:00 p.m. ET)

Ohio State -3.5 (+102)

A real, genuine rarity — plus money on a ranked favorite, while Indiana getting the points costs -124. A 22-cent gap that's one of the clearest signals on the entire slate.

Georgia State at James Madison (Sat, 12:00 p.m. ET)

James Madison -10.5 (+100)

Even money on a double-digit favorite is a real, genuine discount — Georgia State getting the points costs -122, a 22-cent gap favoring the favorite.

North Carolina at Duke (Sat, 3:30 p.m. ET)

Duke -3.5 (+100)

Another real, even-money favorite — North Carolina getting the points costs -122, a genuine 22-cent gap favoring the home side.

Best Over/Under Bets for Saturday's Early Slate

Cincinnati at West Virginia (Sat, 12:00 p.m. ET)

Over 63.5 (-115)

Comfortably the highest total of the entire early slate, a real sign the market expects a genuine track meet between these two Big 12 offenses.

UMass at Buffalo (Sat, 1:00 p.m. ET)

Under 42.5 (-112)

The lowest total of the entire early window, a real sign the market expects a genuinely defensive, grind-it-out MAC matchup.

Western Michigan at Central Michigan (Sat, 1:30 p.m. ET)

Over 43.5 (-104)

The single biggest pricing gap on any total in the early window — the over costs just -104 while the under costs -118, a real 14-cent spread that's the clearest signal on this slate.