College Football Picks: 3 Predictions and Best Bets for Saturday, Nov. 7

College Football Picks in Summary

• Missouri +2.5 (+100)
• Ohio State -7.5 (-110)
• Oklahoma-Florida Under 44.5 (-104)

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This is one of the biggest college football Saturdays of the season, with a slew of headline matchups — several of which will have big ramifications on the college football playoff.

Whether you’re looking for college football picks, predictions, or betting analysis, breaking down the latest odds, matchups, and key trends can help identify the best bets to consider.

Let’s get you ready for this week by looking at our best bets.

All college football odds via FanDuel Sportsbook. Lines may change after this article is published.

College Football Predictions, Picks for Saturday

Missouri +2.5 (+100)

Texas at Missouri — 12:00 p.m. ET

The Missouri Tigers have put together a strong season, and I like them getting points at home against the Texas Longhorns.

Missouri's defense has been excellent, surrendering just 18.4 points and 98.4 rushing yards per game. That should be particularly important against a Texas offense that ranks just 102nd nationally in rushing yards per game (134.3) and 91st in total offense (358.4 yards per game). The Tigers have the defense to give Arch Manning fits, especially with this game in Columbia.

The Tigers also have a significant advantage in turnover margin. Missouri enters with a plus-eight differential, ranking eighth nationally, while Texas sits at minus-three. That's particularly noteworthy in a matchup with such a narrow spread as any turnovers will be big.

Missouri has already recorded convincing home victories over Florida (45-17) and Texas A&M (27-6). Texas certainly has the defensive talent to make this difficult, but Missouri's ability to limit rushing production and generate turnovers makes the Tigers an appealing home underdog.

Ohio State -7.5 (-110)

Oregon at Ohio State — 3:30 p.m. ET

The Ohio State Buckeyes are looking to rebound from a disappointing 30-18 loss to USC, and a home matchup against the Oregon Ducks provides an opportunity to get back on track.

Ohio State has been extremely impressive at Ohio Stadium this season, winning its four home games by margins of 53, 56, 23, and 29 points. The Buckeyes have also demonstrated that they can handle quality Big Ten competition, picking up road victories against Iowa and Indiana. Of course, they no longer have Julian Sayin, but even in the loss at USC, Ohio State had 464 total yards of offense, so they moved the ball plenty well.

Oregon enters with a 5-3 record and has struggled to meet betting expectations, covering the spread in only three of its eight games. The Ducks have also lost three games away from home, adding to the difficulty of Saturday's trip to Columbus, and they’re also starting a backup QB in Dylan Raiola, who has been inconsistent since taking over for Dante Moore.

The Buckeyes have enough defensive talent to create problems for Oregon and Raiola. With the Buckeyes likely needing to win out to make the CFP, I expect them to come out and play really well against the Ducks.

Oklahoma-Florida Under 44.5 (-104)

Oklahoma at Florida — 7:45 p.m. ET

Saturday night's SEC matchup between the Oklahoma Sooners and Florida Gators could turn into a defensive battle, pushing me toward the under.

Oklahoma has struggled to find offensive consistency this season, averaging just 22.0 points per game. The Sooners have been held to 15 or fewer points in four of their eight contests, including scoring just 13 against Kentucky and 10 against Michigan. Oklahoma's defense has been considerably more effective, allowing 20.8 points and 304.6 total yards per game.

Florida has a more productive offense, averaging 35.6 points per game, but the Gators have struggled against stronger competition. They've scored 19 or fewer points in three of their last four games, including just eight in last week's loss to Georgia. That downturn in offensive production is encouraging for the under.

With Oklahoma struggling to generate scoring opportunities and Florida facing a stout Sooners D, this matchup has the ingredients for a relatively low-scoring affair.

College Football Betting FAQ

What is a point spread in college football betting?

The point spread is designed to account for the expected difference between two teams. The favorite must win by more than the listed spread for a bet on that team to cover while the underdog can cover by winning outright or losing by fewer points than the spread.

What is a college football moneyline bet?

A moneyline wager is simply a bet on which team will win the game. Favorites typically have shorter odds and smaller potential payouts while underdogs generally offer larger potential returns.

What does over/under mean in college football?

An over/under, also known as the game total, is a wager on the combined number of points scored by both teams. Bettors can choose whether the final combined score will finish over or under the set total.

What are college football player props?

College football player props are wagers based on an individual player's performance rather than the final outcome of the game. Depending on availability, common markets can include passing yards, rushing yards, receiving yards, touchdowns, and other statistical categories.

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The above author is a FanDuel employee and is not eligible to compete in public daily fantasy contests or place sports betting wagers on FanDuel. The advice provided by the author does not necessarily represent the views of FanDuel. Taking the author's advice will not guarantee a successful outcome. You should use your own judgment when participating in daily fantasy contests or placing sports wagers.