Clemson vs Duke Prediction, Odds, & Betting Trends for College Football Week 1 Game

On Monday in college football, the Clemson Tigers are up against the Duke Blue Devils.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the vital info about today's NCAA football betting odds.

Clemson vs Duke Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Clemson: (-465) | Duke: (+350)
• Spread: Clemson: -12.5 (-115) | Duke: +12.5 (-105)
• Total: 54.5 -- Over: (-115) | Under: (-105)

Clemson vs Duke Betting Trends

• Clemson was 7-7-0 against the spread last season.
• Clemson's ATS record as at least 12.5-point favorites was 3-4 last year.
• There were seven Clemson games (out of 14) that hit the over last season.
• Against the spread, Duke was 9-4-0 last year.
• Out of 13 Duke games last season, five went over the total.

Clemson vs Duke Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Tigers win (70.3%)

Clemson vs Duke Point Spread

Clemson is favored by 12.5 points over Duke. Clemson is -115 to cover the spread, with Duke being -105.

Clemson vs Duke Over/Under

Clemson versus Duke on September 4 has an over/under of 54.5 points, with the over -115 and the under -105.

Clemson vs Duke Moneyline

Clemson is the favorite, -465 on the moneyline, while Duke is a +350 underdog.

Clemson vs. Duke Points Insights

• The average implied total for the Tigers last season was 33.9 points, 0.1 fewer points than their implied total of 34 points in Monday's game.
• Last season, Clemson outscored its implied point total for this matchup (34) seven times.
• The Blue Devils' average implied point total last season (33.2 points) is 12.2 points higher than their implied total in this matchup (21 points).

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Check out even more in-depth Clemson vs. Duke analysis on FanDuel Research.