Giants vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for April 29

Odds updated as of 8:12 a.m.

Tuesday's slate in the MLB includes a matchup between the San Francisco Giants and the San Diego Padres.

All the info you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Giants vs Padres Game Info

• San Francisco Giants (19-10) vs. San Diego Padres (17-11)
• Date: Tuesday, April 29, 2025
• Time: 9:40 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: SDPA and NBCS-BA

Giants vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-120) | SD: (+102)
• Spread: SF: -1.5 (+146) | SD: +1.5 (-176)
• Total: 6.5 -- Over: (-122) | Under: (-100)

Giants vs Padres Probable Starting Pitchers

Probable Pitchers: Logan Webb (Giants) - 3-1, 1.98 ERA vs Nick Pivetta (Padres) - 4-1, 1.20 ERA

The Giants will look to Logan Webb (3-1) versus the Padres and Nick Pivetta (4-1). Webb and his team are 4-2-0 ATS this season when he starts. Webb's team has a record of 3-2 this season when he starts and they are the favorite on the moneyline. When Pivetta starts, the Padres are 4-1-0 against the spread. The Padres were the underdog on the moneyline for two Pivetta starts this season -- they split the games.

Giants vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (55.1%)

Giants vs Padres Moneyline

• San Diego is the underdog, +102 on the moneyline, while San Francisco is a -120 favorite despite being on the road.

Giants vs Padres Spread

• The Giants are at the Padres and are favored by 1.5 runs (+146 to cover) on the runline. San Diego is -176 to cover.

Giants vs Padres Over/Under

• Giants versus Padres, on April 29, has an over/under of 6.5, with the over being -122 and the under -100.

Bet on San Francisco Giants vs. San Diego Padres on FanDuel today!

Giants vs Padres Betting Trends

• The Giants have been chosen as favorites in 18 games this year and have walked away with the win 13 times (72.2%) in those games.
• This year San Francisco has won 11 of 16 games when listed as at least -120 on the moneyline.
• The Giants' games have gone over the total in 16 of their 29 opportunities.
• In 29 games with a line this season, the Giants have a mark of 14-15-0 against the spread.
• The Padres have been the underdog on the moneyline 13 total times this season. They've gone 6-7 in those games.
• San Diego is 4-5 (winning 44.4% of its games) when playing as a moneyline underdog of +102 or longer.
• The Padres have had an over/under set by bookmakers 28 times, and have combined with opponents to go over the total in 10 of those games (10-17-1).
• The Padres have collected a 15-13-0 record against the spread this season (covering 53.6% of the time).

Giants Player Leaders

• Jung Hoo Lee leads San Francisco in slugging percentage (.546) and total hits (35) this season. He's batting .324 with an on-base percentage of .383.
• Among all qualifying hitters in baseball, his batting average ranks ninth, his on-base percentage ranks 24th, and he is 16th in slugging.
• Lee hopes to build on a five-game hitting streak in this matchup. In his last five games he is batting .368 with a double, two walks and an RBI.
• Wilmer Flores has seven home runs and seven walks. He's batting .248 and slugging .455 with an on-base percentage of .303.
• Among qualified hitters, he ranks 75th in batting average, 102nd in on-base percentage and 50th in slugging percentage.
• Matt James Chapman has 21 hits this season and has a slash line of .214/.379/.408.
• Mike Yastrzemski has 23 hits this season and a team-best OBP of .394.
• Yastrzemski brings a two-game hitting streak into this game. During his last five outings he is batting .250 with a home run, a walk and two RBI.

Padres Player Leaders

• Fernando Tatis Jr. has racked up a team-high OBP (.415) and slugging percentage (.625), and leads the Padres in hits (36, while batting .346).
• Including all qualified hitters in the big leagues, his batting average places him fifth, his on-base percentage is seventh, and he is fourth in slugging.
• Tatis heads into this game on a three-game hitting streak. In his last five games he is batting .333 with two doubles, a walk and an RBI.
• Manny Machado is hitting .272 with 10 doubles, two home runs and 10 walks. He's slugging .427 with an on-base percentage of .333.
• He is currently 49th in batting average, 64th in on-base percentage and 63rd in slugging percentage among all qualifying hitters.
• Xander Bogaerts is batting .242 with eight doubles and 13 walks.
• Gavin Sheets is batting .275 with four doubles, three home runs and five walks.

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