Celtics vs. Pistons Prediction, Odds, Picks, Best Bets for Nov. 26

Celtics vs. Pistons Game Info

• Date: Wednesday, November 26, 2025
• Time: 5 p.m. ET
• Venue: TD Garden -- Boston, Massachusetts
• Coverage: ESPN, NBCS-BOS, and FDSDET

The Detroit Pistons (15-2) are only 3-point favorites as they look to continue a seven-game road win streak when they visit the Boston Celtics (9-8) on Wednesday, November 26, 2025 at TD Garden. The game airs at 5 p.m. ET on ESPN, NBCS-BOS, and FDSDET. The matchup's point total is set at 230.5.

Celtics vs. Pistons Odds & Spread

All NBA betting lines, odds and prop bets are from FanDuel Sportsbook.

Celtics vs. Pistons Prediction & Pick

All NBA win probability predictions and picks are according to numberFire.
Prediction: Celtics win (68.5%)

Celtics vs. Pistons Betting Trends

• The Pistons have covered the spread 12 times in 17 games with a set spread.
• The Celtics are 7-9-1 against the spread this year.
• This season, Pistons games have hit the over 10 times.
• Celtics games this season have eclipsed the over/under 41.2% of the time (seven out of 17 games with a set point total).
• Against the spread, Detroit has played better at home, covering seven times in nine home games, and five times in eight road games.
• When it comes to over/unders, the Pistons hit the over more often when playing at home, as they've gone over the total six times in nine opportunities this season (66.7%). On the road, they have hit the over four times in eight opportunities (50%).
• This year, Boston is 4-5-0 at home against the spread (.444 winning percentage). Away, it is 3-4-1 ATS (.375).
• In 2025-26, a higher percentage of the Celtics' games have finished above the over/under at home (55.6%, five of nine) compared to away (25%, two of eight).

Pistons Leaders

• Cade Cunningham is averaging 27.1 points, 6 boards and 9.6 assists. At the other end, he averages 1.3 steals and 0.7 blocked shots.
• Jalen Duren is averaging 20.3 points, 11.5 boards and 2.1 assists. At the other end, he averages 0.9 steals and 0.9 blocked shots.
• Ausar Thompson is averaging 12.6 points, 3 assists and 5.6 rebounds.
• Duncan Robinson's numbers on the season are 12.6 points, 2.9 rebounds and 1.9 assists per game, shooting 44.6% from the field and 41.9% from beyond the arc, with an average of 3.1 made treys.
• Isaiah Stewart averages 10.6 points, 6.1 boards and 1.4 assists, shooting 51.4% from the field and 40% from downtown, with 1.1 made 3-pointers per contest.

Celtics Leaders

• Per game, Jaylen Brown gets the Celtics 27.9 points, 5.6 rebounds and 4.3 assists. He also averages 0.9 steals and 0.3 blocks.
• The Celtics receive 15.4 points per game from Derrick White, plus 4 boards and 5.2 assists.
• The Celtics receive 16.6 points per game from Payton Pritchard, plus 4.3 boards and 5.1 assists.
• Per game, Anfernee Simons gives the Celtics 14.4 points, 2.4 boards and 2.6 assists, plus 0.5 steals and 0.2 blocks.
• Per game, Josh Minott gets the Celtics 7.7 points, 5.1 boards and 1.3 assists, plus 0.9 steals and 0.4 blocks.

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