Celtics vs. 76ers NBA Playoffs Prediction, Odds, Picks, Best Bets for April 28

Celtics vs. 76ers Game Info

• Date: Tuesday, April 28, 2026
• Time: 7 p.m. ET
• Venue: TD Garden -- Boston, Massachusetts
• Coverage: ESPN

The Boston Celtics are massive 11.5-point favorites heading into a decisive Game 5 of the opening round of the NBA Playoffs against the Philadelphia 76ers at TD Garden on Tuesday, starting at 7 p.m. ET on ESPN. The Celtics have a 3-1 lead in the series. The over/under is set at 214.5 in the matchup.

Celtics vs. 76ers Odds & Spread

All NBA betting lines, odds and prop bets are from FanDuel Sportsbook.

Celtics vs. 76ers Prediction & Pick

All NBA win probability predictions and picks are according to numberFire.
Prediction: Celtics win (77.6%)

Celtics vs. 76ers Betting Trends

• The Celtics are 49-32-1 against the spread this season.
• The 76ers have played 82 games, with 40 wins against the spread.
• This season, 30 of the Celtics' games have gone over the point total.
• 76ers games this year have hit the over on 41 of 82 set point totals (50%).
• In home games, Boston owns a worse record against the spread (23-18-0) compared to its ATS record in away games (26-14-1).
• The Celtics have gone over the total in 15 of 41 home games (36.6%). They've done the same in road games, eclipsing the total in 15 of 41 matchups (36.6%).
• This year, Philadelphia is 18-22-1 at home against the spread (.439 winning percentage). Away, it is 22-18-1 ATS (.537).
• In terms of the over/under, 76ers games have finished over less often at home (20 of 41, 48.8%) than on the road (21 of 41, 51.2%).

Celtics Leaders

• Jaylen Brown averages 28.7 points, 6.9 rebounds and 5.1 assists.
• Derrick White is averaging 16.5 points, 5.4 assists and 4.4 boards.
• Payton Pritchard is averaging 17 points, 5.2 assists and 3.9 boards.
• Nikola Vucevic is averaging 15.1 points, 3.3 assists and 8.4 rebounds.
• Neemias Queta is averaging 10.2 points, 8.4 boards and 1.7 assists. At the other end, he averages 0.8 steals and 1.3 blocked shots.

76ers Leaders

• Tyrese Maxey's numbers on the season are 28.3 points, 4.1 rebounds and 6.6 assists per contest. He is also draining 46.2% of his shots from the floor and 36.7% from 3-point range, with an average of 3.1 triples (ninth in NBA).
• The 76ers are getting 16 points, 5.6 boards and 4.2 assists per game from VJ Edgecombe.
• Quentin Grimes averages 13.4 points, 3.6 rebounds and 3.3 assists. He is draining 45% of his shots from the field and 33.4% from 3-point range, with 1.7 triples per contest.
• Per game, Joel Embiid gets the 76ers 26.9 points, 7.7 boards and 3.9 assists, plus 0.6 steals and 1.2 blocks.
• Andre Drummond averages 6.4 points, 8.4 rebounds and 1.3 assists. He is sinking 47.2% of his shots from the field.

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