Cubs vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for April 27

Odds updated as of 6:11 a.m.

The MLB's Monday slate includes the Chicago Cubs facing the San Diego Padres.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Cubs vs Padres Game Info

• Chicago Cubs (17-11) vs. San Diego Padres (18-9)
• Date: Monday, April 27, 2026
• Time: 9:40 p.m. ET
• Venue: Petco Park -- San Diego, California
• Coverage: Padres.TV and MARQ

Cubs vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-116) | SD: (-102)
• Spread: CHC: -1.5 (+150) | SD: +1.5 (-182)
• Total: 8 -- Over: (-110) | Under: (-110)

Cubs vs Padres Probable Starting Pitchers

Probable Pitchers: Matthew Boyd (Cubs) - 1-1, 5.79 ERA vs Randy Vasquez (Padres) - 2-0, 1.88 ERA

The Cubs will call on Matthew Boyd (1-1) against the Padres and Randy Vasquez (2-0). Boyd's team is 2-1-0 against the spread this season in his starts. Boyd's team has won 66.7% of his starts when they are favored on the moneyline (2-1). The Padres have a 4-1-0 ATS record in Vasquez's five starts with a set spread. The Padres were named the moneyline underdog for one Vasquez start this season -- they won.

Cubs vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (54.6%)

Cubs vs Padres Moneyline

• Chicago is a -116 favorite on the moneyline, while San Diego is a -102 underdog at home.

Cubs vs Padres Spread

• The Cubs are at the Padres and are favored by 1.5 runs on the spread. The Cubs are +150 to cover the runline, with the Padres being -182.

Cubs vs Padres Over/Under

• The over/under for the Cubs versus Padres contest on April 27 has been set at 8, with -110 odds on the over and -110 odds on the under.

Bet on Chicago Cubs vs. San Diego Padres on FanDuel today!

Cubs vs Padres Betting Trends

• The Cubs have won in 11, or 61.1%, of the 18 contests they have been named as odds-on favorites in this year.
• Chicago has a record of 10-7 when favored by -116 or more this year.
• The Cubs and their opponents have gone over in 17 of their 28 games with a total set by sportsbooks this season.
• The Cubs have posted a record of 14-14-0 against the spread this season.
• The Padres have won six of the 11 games they were the underdog on the moneyline this season (54.5%).
• San Diego has gone 5-5 in games it has played as a moneyline underdog with odds of -102 or longer (50%).
• The Padres have played in 27 games with an over/under set, and have combined with opponents to go over the total 11 times (11-15-1).
• The Padres have put together a 17-10-0 record against the spread this season.

Cubs Player Leaders

• Nico Hoerner leads Chicago OPS (.855) this season. He has a .307 batting average, an on-base percentage of .382, and a slugging percentage of .474.
• Among qualified hitters in baseball, his batting average ranks 21st, his on-base percentage ranks 22nd, and he is 42nd in slugging.
• Hoerner hopes to build on a three-game hitting streak in this matchup. In his last five games he is batting .227 with two walks and an RBI.
• Dansby Swanson is batting .191 with a double, a triple, six home runs and 19 walks. He's slugging .415 with an on-base percentage of .325.
• His batting average ranks 164th among qualified players, his on-base percentage 103rd, and his slugging percentage 80th.
• Ian Happ leads Chicago in total hits (24) this season, and 11 of those have gone for extra bases.
• Moises Ballesteros is batting .397 with a .446 OBP and 12 RBI for Chicago this season.
• Ballesteros heads into this game on a four-game hitting streak. During his last five outings he is hitting .462 with four doubles, a home run, two walks and two RBIs.

Padres Player Leaders

• Xander Bogaerts has an on-base percentage of .358 and a slugging percentage of .423. Both lead the Padres. He's batting .278.
• Including all the qualifying players in the majors, his batting average puts him 42nd, his on-base percentage is 45th, and he is 73rd in slugging.
• Manny Machado has two doubles, four home runs and 17 walks while batting .209. He's slugging .363 with an on-base percentage of .327.
• He is currently 145th in batting average, 95th in on-base percentage and 124th in slugging percentage among all qualifying batters.
• Ramon Laureano has accumulated 25 hits, a team-best for the Padres.
• Jackson Merrill is hitting .214 with six doubles, three home runs and nine walks.

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