Cardinals vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 28

Odds updated as of 2:14 a.m.

The MLB's Thursday slate includes the St. Louis Cardinals facing the Pittsburgh Pirates.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Cardinals vs Pirates Game Info

• St. Louis Cardinals (65-69) vs. Pittsburgh Pirates (59-75)
• Date: Thursday, August 28, 2025
• Time: 2:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: FDSMW and SportsNet PT

Cardinals vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-122) | PIT: (+104)
• Spread: STL: -1.5 (+162) | PIT: +1.5 (-196)
• Total: 8.5 -- Over: (-108) | Under: (-112)

Cardinals vs Pirates Probable Starting Pitchers

Probable Pitchers: Miles Mikolas (Cardinals) - 6-10, 5.17 ERA vs Braxton Ashcraft (Pirates) - 4-2, 2.70 ERA

This contest's pitching matchup is set, as the Cardinals will send Miles Mikolas (6-10) to the mound, while Braxton Ashcraft (4-2) will take the ball for the Pirates. When Mikolas starts, his team is 10-15-0 against the spread this season. Mikolas' team is 4-3 this season when he starts and they are the moneyline favorite. In all of Ashcraft's four starts that had a set spread, the Pirates covered. The Pirates were named the moneyline underdog for two Ashcraft starts this season -- they won both.

Cardinals vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (52.6%)

Cardinals vs Pirates Moneyline

• The Cardinals vs Pirates moneyline has St. Louis as a -122 favorite, while Pittsburgh is a +104 underdog on the road.

Cardinals vs Pirates Spread

• The Cardinals are 1.5-run home favorites on the runline against the Pirates. The Cardinals are +162 to cover, and the Pirates are -196.

Cardinals vs Pirates Over/Under

• Cardinals versus Pirates, on Aug. 28, has an over/under of 8.5, with the over being -108 and the under -112.

Bet on St. Louis Cardinals vs. Pittsburgh Pirates on FanDuel today!

Cardinals vs Pirates Betting Trends

• The Cardinals have been favorites in 58 games this season and have come away with the win 29 times (50%) in those contests.
• This year St. Louis has won 21 of 41 games when listed as at least -122 on the moneyline.
• The Cardinals and their opponents have gone over in 67 of their 128 games with a total set by sportsbooks this season.
• In 128 games with a line this season, the Cardinals have a mark of 64-64-0 against the spread.
• The Pirates have a 36-50 record in games they were the underdog on the moneyline (winning 41.9% of those games).
• Pittsburgh has a record of 32-45 in games it has played as a moneyline underdog with odds of +104 or longer (41.6%).
• The Pirates have played in 126 games with an over/under set, and have combined with their opponents to go over the total 50 times (50-70-6).
• The Pirates have covered 54.8% of their games this season, going 69-57-0 ATS.

Cardinals Player Leaders

• Alec Burleson has 123 hits to go with a slugging percentage of .454, both of which are tops among St. Louis hitters this season. He has a .288 batting average and an on-base percentage of .338.
• Among qualifying hitters in the majors, his batting average ranks 17th, his on-base percentage ranks 61st, and he is 57th in slugging.
• Willson Contreras has 30 doubles, 19 home runs and 40 walks. He's batting .257 and slugging .451 with an on-base percentage of .341.
• Among qualifiers, he is 82nd in batting average, 55th in on-base percentage and 60th in slugging percentage.
• Masyn Winn has 117 hits this season and has a slash line of .256/.312/.372.
• Lars Nootbaar has 13 home runs, 44 RBI and a batting average of .233 this season.

Pirates Player Leaders

• Bryan Reynolds has a slugging percentage of .411 and has 122 hits, both team-best marks for the Pirates. He's batting .246 and with an on-base percentage of .306.
• He ranks 104th in batting average, 121st in on-base percentage and 92nd in slugging percentage among all qualifying batters in MLB.
• Oneil Cruz has 17 doubles, two triples, 18 home runs and 56 walks while batting .203. He's slugging .391 with an on-base percentage of .302.
• He is 154th in batting average, 125th in on-base percentage and 118th in slugging percentage in the majors.
• Andrew McCutchen a has .332 on-base percentage to pace the Pirates.
• Isiah Kiner-Falefa is batting .270 with 20 doubles, two triples, a home run and 17 walks.

Cardinals vs Pirates Head to Head

• 8/27/2025: 2-1 PIT (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 8/26/2025: 8-3 PIT (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/25/2025: 7-6 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/2/2025: 5-0 PIT (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/1/2025: 1-0 PIT (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 5/7/2025: 5-0 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 5/6/2025: 2-1 STL (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 5/5/2025: 6-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 4/9/2025: 2-1 PIT (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/8/2025: 5-3 STL (Favorite: Pirates, Spread: -1.5, Total: 6.5, Favorite Moneyline: -138, Underdog Moneyline: +118)

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