Cardinals vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 20

Odds updated as of 9:12 p.m.

MLB action on Sunday includes the St. Louis Cardinals taking on the Washington Nationals.

We've got you covered, in terms of the most important info regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Cardinals vs Nationals Game Info

• St. Louis Cardinals (75-79) vs. Washington Nationals (72-82)
• Date: Sunday, September 20, 2026
• Time: 2:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: Cardinals.TV and Nationals.TV

Cardinals vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-144) | WSH: (+122)
• Spread: STL: -1.5 (+150) | WSH: +1.5 (-182)
• Total: 9.5 -- Over: (+116) | Under: (-142)

Cardinals vs Nationals Probable Starting Pitchers

Probable Pitchers: Quinn Mathews (Cardinals) - 2-3, 3.62 ERA vs Jake Irvin (Nationals) - 2-9, 5.51 ERA

This contest's pitching matchup is set, as the Cardinals will send Quinn Mathews (2-3) to the mound, while Jake Irvin (2-9) will answer the bell for the Nationals. When Mathews starts, his team is 2-5-0 against the spread this season. Mathews' team has a record of 2-1 this season when he starts and they are the favorite on the moneyline. The Nationals have a 12-7-0 ATS record in Irvin's 19 starts with a set spread. The Nationals have a 7-10 record in Irvin's 17 starts this season when they were the moneyline underdog.

Cardinals vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (55.4%)

Cardinals vs Nationals Moneyline

• The moneyline numbers for Cardinals vs. Nationals reveal St. Louis as the favorite (-144) and Washington as the underdog (+122) on the road.

Cardinals vs Nationals Spread

• The Nationals are at +1.5 on the runline against the Cardinals. The Nationals are -182 to cover the spread, and the Cardinals are +150.

Cardinals vs Nationals Over/Under

• An over/under of 9.5 has been set for Cardinals-Nationals on Sept. 20, with the over being +116 and the under -142.

Bet on St. Louis Cardinals vs. Washington Nationals on FanDuel today!

Cardinals vs Nationals Betting Trends

• The Cardinals have come away with 27 wins in the 51 contests they have been listed as the favorites in this season.
• St. Louis has a record of 6-4 when favored by -144 or more this year.
• The Cardinals and their opponents have gone over the total this season in 70 of their 150 opportunities.
• The Cardinals are 80-70-0 against the spread in their 150 games that had a posted line this season.
• The Nationals have gone 49-66 in games they were listed as the moneyline underdog (winning 42.6% of those games).
• Washington is 25-45 (winning just 35.7% of its games) when playing as a moneyline underdog of +122 or longer.
• In the 150 games oddsmakers have set an over/under for the Nationals, they have combined with opponents to go over the total 79 times (79-65-6).
• The Nationals have an 82-68-0 record against the spread this season (covering 54.7% of the time).

Cardinals Player Leaders

• Alec Burleson leads St. Louis with a slugging percentage of .469, fueled by 61 extra-base hits. He has a .283 batting average and an on-base percentage of .349.
• Among qualified hitters in MLB, his batting average ranks 18th, his on-base percentage ranks 43rd, and he is 32nd in slugging.
• Jordan Walker leads St. Louis with 161 hits. He is batting .279 this season and has 61 extra-base hits. He's also slugging .481 with an on-base percentage of .336.
• His batting average is 24th among qualified players, his on-base percentage 63rd, and his slugging percentage 27th.
• Ivan Herrera leads St. Louis with an OBP of .355 this season while batting .242 with 74 walks and 93 runs scored.
• JJ Wetherholt is batting .240 with a .341 OBP and 48 RBI for St. Louis this season.

Nationals Player Leaders

• C.J. Abrams has put up a team-high .493 slugging percentage. He's batting .264 with an on-base percentage of .338.
• He ranks 55th in batting average, 58th in on-base percentage and 18th in slugging percentage among all qualifying hitters in the big leagues.
• Abrams hopes to build on a five-game hitting streak in this matchup. During his last five outings he is hitting .381 with four doubles and two RBIs.
• James Wood paces his team with 128 hits and a .392 on-base percentage. He has a batting average of .266 while slugging .519.
• Including all qualified hitters, he is 50th in batting average, third in on-base percentage and ninth in slugging percentage.
• Daylen Lile is batting .250 with 27 doubles, eight triples, 21 home runs and 40 walks.
• Jacob Young is batting .248 with 21 doubles, three triples, 10 home runs and 33 walks.

Cardinals vs Nationals Head to Head

• 9/18/2026: 9-1 WSH (Favorite: Nationals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/8/2026: 6-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 4/7/2026: 7-6 STL (Favorite: Nationals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/6/2026: 9-6 WSH (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/10/2025: 8-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/9/2025: 8-2 WSH (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/11/2025: 6-1 STL (Favorite: Nationals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/10/2025: 4-2 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/9/2025: 10-0 STL (Favorite: Nationals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 7/28/2024: 4-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!