Cardinals vs Brewers Prediction, Odds, Moneyline, Spread & Over/Under for May 5

Odds updated as of 5:12 a.m.

The St. Louis Cardinals are among the MLB teams playing on Tuesday, up against the Milwaukee Brewers.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Cardinals vs Brewers Game Info

• St. Louis Cardinals (21-14) vs. Milwaukee Brewers (18-16)
• Date: Tuesday, May 5, 2026
• Time: 7:45 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: Cardinals.TV and Brewers.TV

Cardinals vs Brewers Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-112) | MIL: (-104)
• Spread: STL: +1.5 (-200) | MIL: -1.5 (+164)
• Total: 7.5 -- Over: (-118) | Under: (-104)

Cardinals vs Brewers Probable Starting Pitchers

Probable Pitchers: Andre Pallante (Cardinals) - 3-2, 3.73 ERA vs Brandon Sproat (Brewers) - 0-2, 6.75 ERA

The Cardinals will give the nod to Andre Pallante (3-2) versus the Brewers and Brandon Sproat (0-2). Pallante and his team have a record of 4-2-0 against the spread when he starts. Pallante's team lost his only start as a favorite this season. The Brewers have gone 3-1-0 ATS in Sproat's four starts that had a set spread. The Brewers were the underdog on the moneyline for one Sproat start this season -- they lost.

Cardinals vs Brewers Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (52.8%)

Cardinals vs Brewers Moneyline

• Looking at the moneyline for Cardinals-Brewers, St. Louis is the favorite at -112, and Milwaukee is -104 playing on the road.

Cardinals vs Brewers Spread

• The Brewers are 1.5-run favorites against the spread for this matchup with the Cardinals. The Brewers are +164 to cover, while the Cardinals are -200 to cover as a 1.5-run underdog on the runline.

Cardinals vs Brewers Over/Under

• An over/under of 7.5 has been set for Cardinals-Brewers on May 5, with the over being -118 and the under -104.

Bet on St. Louis Cardinals vs. Milwaukee Brewers on FanDuel today!

Cardinals vs Brewers Betting Trends

• The Cardinals have been victorious in two of the three contests they have been chosen as favorites in this season.
• This year St. Louis has won two of three games when listed as at least -112 on the moneyline.
• The Cardinals and their opponents have gone over in 18 of their 35 games with a total set by sportsbooks this season.
• The Cardinals are 22-13-0 against the spread in their 35 games that had a posted line this season.
• The Brewers have won 36.4% of the games this season they were the underdog on the moneyline (4-7).
• When playing as a moneyline underdog with odds of -104 or longer, Milwaukee has a 2-5 record (winning just 28.6% of its games).
• In the 34 games oddsmakers have set an over/under for the Brewers, they have combined with opponents to go over the total 17 times (17-16-1).
• The Brewers are 20-14-0 ATS this season.

Cardinals Player Leaders

• Jordan Walker has 40 hits to go with a slugging percentage of .585, both of which rank first among St. Louis hitters this season. He has a .308 batting average and an on-base percentage of .377.
• Among all qualified batters in the majors, he is 20th in batting average, 34th in on-base percentage, and seventh in slugging.
• Alec Burleson has nine doubles, five home runs and 17 walks. He's batting .269 and slugging .448 with an on-base percentage of .349.
• He is 55th in batting average, 65th in on-base percentage and 54th in slugging in the majors.
• JJ Wetherholt has 33 hits this season and has a slash line of .246/.360/.440.
• Wetherholt heads into this game with two games in a row with at least one hit. In his last five games he is batting .238 with a home run, two walks and three RBIs.
• Ivan Herrera has 32 hits this season and a team-best OBP of .416.

Brewers Player Leaders

• Brice Turang has put up a team-best OBP (.434), while leading the Brewers in hits (35). He's batting .304 and slugging.
• Including all the qualifying players in the majors, he is 24th in batting average, third in on-base percentage and 23rd in slugging percentage.
• Turang heads into this game on a six-game hitting streak. In his last 10 games he is batting .324 with three doubles, a home run, eight walks and four RBIs.
• William Contreras is slugging .411 to lead his team. He has a batting average of .287 with an on-base percentage of .357.
• He is currently 38th in batting average, 56th in on-base percentage and 83rd in slugging percentage among all qualified hitters.
• Jake Bauers is batting .248 with six doubles, five home runs and 13 walks.
• Sal Frelick is hitting .212 with two doubles, three home runs and 15 walks.

Cardinals vs Brewers Head to Head

• 5/4/2026: 6-3 STL (Favorite: Brewers, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/21/2025: 5-1 STL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/20/2025: 3-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/19/2025: 7-1 STL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/14/2025: 3-2 STL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 9/13/2025: 9-8 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 9/12/2025: 8-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 6/15/2025: 3-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 6/14/2025: 8-5 STL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/13/2025: 3-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)

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