Broncos vs Cardinals Prediction, Odds, Picks, Best Bets for NFL Week 7

The Sunday schedule in the NFL includes a matchup between the Denver Broncos and the Arizona Cardinals.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NFL moneyline insights you need to know.

Broncos vs Cardinals Prediction & Pick

All NFL win probability predictions and picks are according to numberFire.
Prediction: Broncos win (62.9%)

Broncos vs Cardinals Point Spread

The Broncos are 4.5-point favorites against the Cardinals. The Broncos are -110 to cover the spread, while the Cardinals are -110 to cover as a 4.5-point underdog.

Broncos vs Cardinals Over/Under

A total of 43.5 points has been set for the Broncos-Cardinals matchup on Oct. 25, with the over available at -110 and the under at -110.

Broncos vs Cardinals Moneyline

The Broncos vs Cardinals moneyline has Denver as a -240 favorite, while Arizona is a +198 underdog at home.

Broncos vs Cardinals Betting Trends

• Denver's record against the spread is 4-2-0.
• The Broncos have had one game (out of six) hit the over this year.
• Against the spread, the Cardinals are 3-3-0 this year.
• Arizona is 3-2 as 4.5-point or bigger underdogs in 2026.
• The Cardinals have played six games this season, and three of them have gone over the total.

Check out even more in-depth Broncos vs. Cardinals analysis on FanDuel Research.

Broncos vs Cardinals Odds & Spread

• All NFL odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: DEN: (-240) | ARI: (+198)
• Spread: DEN: -4.5 (-110) | ARI: +4.5 (-110)
• Total: 43.5 -- Over: (-110) | Under: (-110)

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