Brewers vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 6

Odds updated as of 2:16 a.m.

The Milwaukee Brewers are among the MLB teams in action on Saturday, versus the Pittsburgh Pirates.

All the info you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Brewers vs Pirates Game Info

• Milwaukee Brewers (87-55) vs. Pittsburgh Pirates (64-78)
• Date: Saturday, September 6, 2025
• Time: 6:40 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: SportsNet PT and FDSWI

Brewers vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIL: (-156) | PIT: (+132)
• Spread: MIL: -1.5 (+115) | PIT: +1.5 (-138)
• Total: 8 -- Over: (-106) | Under: (-114)

Brewers vs Pirates Probable Starting Pitchers

Probable Pitchers: Brandon Woodruff (Brewers) - 5-2, 3.69 ERA vs Mitch Keller (Pirates) - 6-13, 4.21 ERA

This contest's pitching matchup is set, as the Brewers will send Brandon Woodruff (5-2) to the mound, while Mitch Keller (6-13) will answer the bell for the Pirates. Woodruff's team is 5-5-0 against the spread in his starts this season. Woodruff's team has won 75% of his starts when they are favored on the moneyline (6-2). The Pirates have a 16-11-0 record against the spread in Keller's starts. The Pirates have a 9-12 record in Keller's 21 starts this season when they were the moneyline underdog.

Brewers vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Brewers win (52.5%)

Brewers vs Pirates Moneyline

• The moneyline numbers for Brewers vs. Pirates reveal Milwaukee as the favorite (-156) and Pittsburgh as the underdog (+132) despite being the home team.

Brewers vs Pirates Spread

• The Brewers are at the Pirates and are favored by 1.5 runs on the spread. The Brewers are +115 to cover the runline, with the Pirates being -138.

Brewers vs Pirates Over/Under

• The over/under for the Brewers versus Pirates game on Sept. 6 has been set at 8, with -106 odds on the over and -114 odds on the under.

Bet on Milwaukee Brewers vs. Pittsburgh Pirates on FanDuel today!

Brewers vs Pirates Betting Trends

• The Brewers have been victorious in 51, or 65.4%, of the 78 contests they have been chosen as favorites in this season.
• This season Milwaukee has come away with a win 17 times in 23 chances when named as a favorite of at least -156 on the moneyline.
• The Brewers and their opponents have gone over the total this season in 69 of their 139 opportunities.
• The Brewers have posted a record of 79-60-0 against the spread this season.
• The Pirates have won 43.6% of the games this season they were the underdog on the moneyline (41-53).
• In games it has played as a moneyline underdog with odds of +132 or longer, Pittsburgh has a record of 18-28 (39.1%).
• In the 134 games bookmakers have set an over/under for the Pirates, they have combined with opponents to go over the total 53 times (53-75-6).
• The Pirates have a 74-60-0 record ATS this season (covering 55.2% of the time).

Brewers Player Leaders

• William Contreras is batting .263 with 26 doubles, 17 home runs and 77 walks. He has an on-base percentage of .358 while slugging .411.
• Among qualifying hitters in MLB, he ranks 63rd in batting average, 24th in on-base percentage, and 94th in slugging.
• Contreras will look for his sixth straight game with a hit in this contest. In his last five games he is hitting .381 with a double, a home run, two walks and three RBIs.
• Brice Turang has an OPS of .807, fueled by an OBP of .358 and a team-best slugging percentage of .448 this season. He's batting .292.
• Among qualified hitters, his batting average places him 14th, his on-base percentage 24th, and his slugging percentage 63rd.
• Christian Yelich is batting .268 with a .464 slugging percentage and 92 RBI this year.
• Jackson Chourio has 129 hits, which leads Milwaukee hitters this season, while batting .276 with 53 extra-base hits.

Pirates Player Leaders

• Bryan Reynolds has accumulated a team-high slugging percentage (.408) and leads the Pirates in hits (127). He's batting .245 and with an on-base percentage of .313.
• Including all qualifying hitters in the big leagues, he ranks 107th in batting average, 110th in on-base percentage and 98th in slugging percentage.
• Oneil Cruz is batting .205 with 17 doubles, two triples, 19 home runs and 59 walks. He's slugging .390 with an on-base percentage of .305.
• Including all qualified hitters, he ranks 151st in batting average, 123rd in on-base percentage and 120th in slugging percentage.
• Andrew McCutchen a has .339 on-base percentage to pace the Pirates.
• Tommy Pham is batting .264 with 17 doubles, a triple, eight home runs and 39 walks.

Brewers vs Pirates Head to Head

• 9/5/2025: 5-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 8/13/2025: 12-5 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -240, Underdog Moneyline: +198)
• 8/12/2025: 14-0 MIL (Favorite: Brewers, Spread: -1.5, Total: 6.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 8/11/2025: 7-1 MIL (Favorite: Brewers, Spread: -1.5, Total: 9, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 6/25/2025: 4-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 6.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 6/24/2025: 9-3 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 6/23/2025: 5-4 PIT (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -180, Underdog Moneyline: +152)
• 5/25/2025: 6-5 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 5/24/2025: 2-1 PIT (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 5/23/2025: 6-5 PIT (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -124, Underdog Moneyline: +106)

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