Brewers vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for May 27

Odds updated as of 10:12 p.m.

The Milwaukee Brewers will take on the St. Louis Cardinals in MLB action on Wednesday.

All the information you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Brewers vs Cardinals Game Info

• Milwaukee Brewers (31-20) vs. St. Louis Cardinals (29-23)
• Date: Wednesday, May 27, 2026
• Time: 1:40 p.m. ET
• Venue: American Family Field -- Milwaukee, Wisconsin
• Coverage: Brewers.TV and Cardinals.TV

Brewers vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIL: (-146) | STL: (+124)
• Spread: MIL: -1.5 (+150) | STL: +1.5 (-182)
• Total: 8.5 -- Over: (-105) | Under: (-115)

Brewers vs Cardinals Probable Starting Pitchers

Probable Pitchers: TBA (Brewers) vs Dustin May (Cardinals) - 3-5, 0.00 ERA

The Cardinals will give the nod to May (3-5, 4.96), while the Brewers' starter for this game has yet to be determined. The Cardinals are 5-5-0 against the spread when May starts. The Cardinals have a 3-5 record in May's eight starts this season when they were the moneyline underdog.

Brewers vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Brewers win (62.7%)

Brewers vs Cardinals Moneyline

• Looking at the moneyline for Brewers-Cardinals, Milwaukee is the favorite at -146, and St. Louis is +124 playing on the road.

Brewers vs Cardinals Spread

• The Brewers are 1.5-run home favorites on the runline against the Cardinals. The Brewers are +150 to cover, and the Cardinals are -182.

Brewers vs Cardinals Over/Under

• An over/under of 8.5 has been set for Brewers-Cardinals on May 27, with the over being -105 and the under -115.

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Brewers vs Cardinals Betting Trends

• The Brewers have been favorites in 30 games this season and have come away with the win 19 times (63.3%) in those contests.
• Milwaukee has a record of 6-6 in contests when oddsmakers favor them by -146 or more on the moneyline.
• The Brewers and their opponents have hit the over in 22 of their 51 games with a total set by oddsmakers this season.
• The Brewers have posted a record of 31-20-0 against the spread this season.
• The Cardinals have been the moneyline underdog 42 total times this season. They've finished 24-18 in those games.
• In games it has played as a moneyline underdog with odds of +124 or longer, St. Louis has a 7-5 record (winning 58.3% of its games).
• The Cardinals have played in 51 games with an over/under set, and have combined with opponents to go over the total 22 times (22-25-4).
• The Cardinals have a 30-21-0 record ATS this season (covering 58.8% of the time).

Brewers Player Leaders

• Brice Turang has 51 hits this season and a team-best OBP of .410. He has a .287 batting average and a slugging percentage of .478.
• Among all qualified hitters in the majors, he ranks 30th in batting average, fourth in on-base percentage, and 34th in slugging.
• William Contreras has an OPS of .772, fueled by an OBP of .369 and a team-best slugging percentage of .403 this season. He's batting .298.
• Among qualified hitters, his batting average places him 18th, his on-base percentage 28th, and his slugging percentage 82nd.
• Contreras enters this game looking to extend his nine-game hit streak. In his last 10 outings he is batting .366 with a home run, four walks and five RBIs.
• Jake Bauers leads Milwaukee in total hits (45) this season, and 17 of those have gone for extra bases.
• Sal Frelick has three home runs, 18 RBI and a batting average of .217 this season.

Cardinals Player Leaders

• Jordan Walker has a team-best slugging percentage (.585) and paces the Cardinals in hits (58). He's batting .297 and with an on-base percentage of .367.
• Including all the qualifying players in the majors, his batting average puts him 19th, his on-base percentage ranks 33rd, and he is fourth in slugging.
• Alec Burleson is hitting .288 with 13 doubles, seven home runs and 21 walks. He's slugging .460 with an on-base percentage of .359.
• He is 29th in batting average, 40th in on-base percentage and 45th in slugging percentage in MLB.
• JJ Wetherholt is batting .239 with five doubles, nine home runs and 28 walks.
• Ivan Herrera leads his team with a .387 on-base percentage.

Brewers vs Cardinals Head to Head

• 5/25/2026: 5-1 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 5/6/2026: 6-2 MIL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 5/4/2026: 6-3 STL (Favorite: Brewers, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/21/2025: 5-1 STL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/20/2025: 3-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/19/2025: 7-1 STL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/14/2025: 3-2 STL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 9/13/2025: 9-8 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 9/12/2025: 8-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 6/15/2025: 3-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +116)

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