Bills vs Patriots Prediction, Odds, Picks, Best Bets for NFL Week 16

In NFL action on Sunday, the Buffalo Bills play the New England Patriots.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NFL moneyline insights you need to know.

Bills vs Patriots Prediction & Pick

All NFL win probability predictions and picks are according to numberFire.
Prediction: Bills win (88.2%)

Bills vs Patriots Point Spread

The Bills are 14.5-point favorites against the Patriots. The Bills are -102 to cover the spread, while the Patriots are -120 to cover as a 14.5-point underdog.

Bills vs Patriots Over/Under

A total of 46.5 points has been set for the Bills-Patriots game on Dec. 22, with the over available at -110 and the under at -110.

Bills vs Patriots Moneyline

The moneyline numbers for Bills vs. Patriots reveal Buffalo as the favorite (-1205) and New England as the underdog (+750) on the road.

Bills vs Patriots Betting Trends

• Buffalo is 9-5-0 against the spread this year.
• The Bills have seen 10 of their 14 games go over the point total.
• The Patriots are 6-8-0 against the spread this season.
• There have been nine Patriots games (out of 14) that went over the total this year.

Bills vs Patriots Odds & Spread

• All NFL odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BUF: (-1205) | NE: (+750)
• Spread: BUF: -14.5 (-102) | NE: +14.5 (-120)
• Total: 46.5 -- Over: (-110) | Under: (-110)

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