Best College Football Games Week 5: Predictions, Odds, Picks, Best Bets

A total of 16 games on the Week 5 college football schedule feature a ranked team, including the matchup between the No. 5 Ohio State Buckeyes and the No. 14 Iowa Hawkeyes.

With Week 5 in college football upon us, stay on top of the latest betting trends with our preview below.

For additional insights, check out the latest college football betting picks from FanDuel Research's staff of writers.

SMU vs. Boston College

• Matchup: Boston College Eagles at No. 21 SMU Mustangs
• Projected Favorite: SMU (91.22% win probability)
• Spread: SMU (-20.5)
• Total: 55.5
• Time: 12 p.m. ET
• Date: Oct. 3
• TV Channel: The CW

Bet on SMU vs. Boston College with FanDuel Sportsbook.

Mississippi State vs. Alabama

• Matchup: No. 7 Alabama Crimson Tide at No. 16 Mississippi State Bulldogs
• Projected Favorite: Alabama (66.26% win probability)
• Spread: Alabama (-5.5)
• Total: 60.5
• Time: 12 p.m. ET
• Date: Oct. 3
• TV Channel: ABC

Bet on Mississippi State vs. Alabama with FanDuel Sportsbook.

Houston vs. UCF

• Matchup: UCF Knights at No. 20 Houston Cougars
• Projected Favorite: Houston (76.83% win probability)
• Spread: Houston (-12.5)
• Total: 51.5
• Time: 12 p.m. ET
• Date: Oct. 3
• TV Channel: ESPN2

Bet on Houston vs. UCF with FanDuel Sportsbook.

North Carolina vs. Notre Dame

• Matchup: No. 3 Notre Dame Fighting Irish at North Carolina Tar Heels
• Projected Favorite: Notre Dame (92.27% win probability)
• Spread: Notre Dame (-21.5)
• Total: 47.5
• Time: 12 p.m. ET
• Date: Oct. 3
• TV Channel: ESPN

Bet on North Carolina vs. Notre Dame with FanDuel Sportsbook.

Georgia vs. Vanderbilt

• Matchup: Vanderbilt Commodores at No. 2 Georgia Bulldogs
• Projected Favorite: Georgia (87.87% win probability)
• Spread: Georgia (-24.5)
• Total: 51.5
• Time: 12:45 p.m. ET
• Date: Oct. 3
• TV Channel: SEC Network

Bet on Georgia vs. Vanderbilt with FanDuel Sportsbook.

Tennessee vs. Auburn

• Matchup: Auburn Tigers at No. 17 Tennessee Volunteers
• Projected Favorite: Tennessee (70.25% win probability)
• Spread: Tennessee (-6.5)
• Total: 54.5
• Time: 3:30 p.m. ET
• Date: Oct. 3
• TV Channel: ESPN

Bet on Tennessee vs. Auburn with FanDuel Sportsbook.

Iowa vs. Ohio State

• Matchup: No. 5 Ohio State Buckeyes at No. 14 Iowa Hawkeyes
• Projected Favorite: Ohio State (69.11% win probability)
• Spread: Ohio State (-14.5)
• Total: 45.5
• Time: 3:30 p.m. ET
• Date: Oct. 3
• TV Channel: CBS

Bet on Iowa vs. Ohio State with FanDuel Sportsbook.

Missouri vs. Florida

• Matchup: No. 8 Florida Gators at No. 25 Missouri Tigers
• Projected Favorite: Florida (50.40% win probability)
• Spread: Florida (-4.5)
• Total: 56.5
• Time: 3:30 p.m. ET
• Date: Oct. 3
• TV Channel: ABC

Bet on Missouri vs. Florida with FanDuel Sportsbook.

South Carolina vs. Kentucky

• Matchup: No. 24 Kentucky Wildcats at South Carolina Gamecocks
• Projected Favorite: South Carolina (59.68% win probability)
• Spread: South Carolina (-2.5)
• Total: 53.5
• Time: 4:15 p.m. ET
• Date: Oct. 3
• TV Channel: SEC Network

Bet on South Carolina vs. Kentucky with FanDuel Sportsbook.

TCU vs. BYU

• Matchup: No. 10 BYU Cougars at TCU Horned Frogs
• Projected Favorite: BYU (71.69% win probability)
• Spread: BYU (-6.5)
• Total: 47.5
• Time: 7 p.m. ET
• Date: Oct. 3
• TV Channel: ESPN

Bet on TCU vs. BYU with FanDuel Sportsbook.

Boise State vs. Utah State

• Matchup: Utah State Aggies at No. 22 Boise State Broncos
• Projected Favorite: Boise State (87.84% win probability)
• Spread: Boise State (-20.5)
• Total: 51.5
• Time: 7:30 p.m. ET
• Date: Oct. 3
• TV Channel: CBS Sports Network

Bet on Boise State vs. Utah State with FanDuel Sportsbook.

USC vs. Washington

• Matchup: Washington Huskies at No. 18 USC Trojans
• Projected Favorite: USC (79.75% win probability)
• Spread: USC (-9.5)
• Total: 58.5
• Time: 7:30 p.m. ET
• Date: Oct. 3
• TV Channel: NBC

Bet on USC vs. Washington with FanDuel Sportsbook.

Colorado vs. Texas Tech

• Matchup: No. 12 Texas Tech Red Raiders at Colorado Buffaloes
• Projected Favorite: Texas Tech (94.05% win probability)
• Spread: Texas Tech (-11.5)
• Total: 50.5
• Time: 7:30 p.m. ET
• Date: Oct. 3
• TV Channel: FOX

Bet on Colorado vs. Texas Tech with FanDuel Sportsbook.

Clemson vs. Miami (FL)

• Matchup: No. 4 Miami Hurricanes at Clemson Tigers
• Projected Favorite: Miami (FL) (86.41% win probability)
• Spread: Miami (FL) (-16.5)
• Total: 47.5
• Time: 7:30 p.m. ET
• Date: Oct. 3
• TV Channel: ABC

Bet on Clemson vs. Miami (FL) with FanDuel Sportsbook.

LSU vs. McNeese

• Matchup: McNeese Cowboys at No. 11 LSU Tigers
• Projected Favorite: LSU
• Spread: LSU (-53.5)
• Total: 61.5
• Time: 7:45 p.m. ET
• Date: Oct. 3
• TV Channel: SEC Network

Bet on LSU vs. McNeese with FanDuel Sportsbook.

Rutgers vs. Indiana

• Matchup: No. 6 Indiana Hoosiers at Rutgers Scarlet Knights
• Projected Favorite: Indiana (95.67% win probability)
• Spread: Indiana (-23.5)
• Total: 55.5
• Time: 8 p.m. ET
• Date: Oct. 3
• TV Channel: BTN

Bet on Rutgers vs. Indiana with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

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