Ball State vs Ohio State Prediction, College Football Picks, Odds & Best Bets Today

College Football Betting Picks in Summary

• Ohio State -49.5
• Over 56.5
• Ohio State Over 562.5 Total Yards

Ball State travels to Ohio State Saturday afternoon in one of the widest spreads anywhere on the college football board — a 49.5-point line with no moneyline even posted, a real sign of just how lopsided the market considers this one.

All college football odds come from FanDuel Sportsbook's college football betting odds and may change after this article is published.

College Football Predictions and Picks

Ball State at Ohio State (Sat, 12:30 p.m. ET)

Ohio State -49.5 (-115)

The nation's top-ranked team is favored by more than 49 points at home, with a first-half spread alone sitting at -28.5 — a real sign this one figures to be decided long before the fourth quarter even starts.

Over 56.5 (-110)

Ohio State's own projected yardage output (562.5) is enough on its own to comfortably clear this total, regardless of how little Ball State manages to put up on the other side.

Ohio State Over 562.5 Total Yards (-114)

Ball State's own team total sits at just 128.5 yards for the entire game — nearly a quarter of what Ohio State alone is projected to produce, making this about as clean a talent gap as the board offers all season.