Astros vs Royals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 17

Odds updated as of 2:12 a.m.

The MLB's Thursday schedule includes the Houston Astros facing the Kansas City Royals.

All the information you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Astros vs Royals Game Info

• Houston Astros (76-76) vs. Kansas City Royals (67-85)
• Date: Thursday, September 17, 2026
• Time: 7:15 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: FOX

Astros vs Royals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-162) | KC: (+136)
• Spread: HOU: -1.5 (+126) | KC: +1.5 (-152)
• Total: 8.5 -- Over: (-124) | Under: (+102)

Astros vs Royals Probable Starting Pitchers

Probable Pitchers: Miguel Ullola (Astros) - 0-0, 3.38 ERA vs Seth Lugo (Royals) - 7-8, 4.99 ERA

The probable pitchers are Miguel Ullola for the Astros and Seth Lugo (7-8) for the Royals. Ullola and his team failed to cover the spread in his only opportunity this season as a starter. This will be Ullola's first start this season with his team as the moneyline favorite. The Royals have a 17-13-0 ATS record in Lugo's 30 starts with a set spread. The Royals are 10-11 in Lugo's 21 starts this season that they were the moneyline underdog.

Astros vs Royals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (55.2%)

Astros vs Royals Moneyline

• The Astros vs Royals moneyline has Houston as a -162 favorite, while Kansas City is a +136 underdog on the road.

Astros vs Royals Spread

• The Royals are at +1.5 on the runline against the Astros. The Royals are -152 to cover the spread, and the Astros are +126.

Astros vs Royals Over/Under

• Astros versus Royals on Sept. 17 has an over/under of 8.5 runs, with the odds on the over -124 and the under set at +102.

Bet on Houston Astros vs. Kansas City Royals on FanDuel today!

Astros vs Royals Betting Trends

• The Astros have been favorites in 65 games this season and have come away with the win 34 times (52.3%) in those contests.
• Houston has a record of 7-10 in contests when bookmakers favor them by -162 or more on the moneyline.
• The Astros and their opponents have gone over in 75 of their 152 games with a total set by sportsbooks this season.
• In 152 games with a line this season, the Astros have a mark of 76-76-0 against the spread.
• The Royals have compiled a 38-56 record in games they were listed as the moneyline underdog (winning 40.4% of those games).
• Kansas City has a 7-15 record (winning only 31.8% of its games) when it has played as a moneyline underdog of +136 or longer.
• The Royals have played in 145 games with a set over/under, and have combined with their opponents to go over the total 65 times (65-77-3).
• The Royals have a 75-70-0 record against the spread this season (covering 51.7% of the time).

Astros Player Leaders

• Yordan Alvarez leads Houston with 164 hits and an OBP of .428, plus a team-best slugging percentage of .594. He's batting .310.
• Among all qualifying batters, he ranks second in batting average, his on-base percentage ranks first, and he is first in slugging.
• Alvarez hopes to build on a two-game hitting streak in this matchup. In his last five games he is batting .267 with two doubles, a home run, four walks and three RBIs.
• Isaac Paredes has 26 doubles, a triple, 21 home runs and 64 walks. He's batting .257 and slugging .430 with an on-base percentage of .354.
• Among qualifying hitters, his batting average places him 68th, his on-base percentage 37th, and his slugging percentage 64th.
• Christian Walker has collected 119 base hits, an OBP of .295 and a slugging percentage of .412 this season.
• Jeremy Pena is batting .277 with a .329 OBP and 49 RBI for Houston this season.
• Pena heads into this matchup on a two-game hitting streak. During his last five outings he is hitting .412 with a double, two home runs, a walk and two RBIs.

Royals Player Leaders

• Bobby Witt Jr. has a team-best OBP (.359) and slugging percentage (.444). He's batting .278.
• Including all qualified hitters in the majors, he ranks 25th in batting average, 33rd in on-base percentage and 51st in slugging percentage.
• Carter Jensen is batting .232 with 33 doubles, two triples, 24 home runs and 63 walks. He's slugging .453 with an on-base percentage of .319.
• He is currently 110th in batting average, 87th in on-base percentage and 43rd in slugging percentage among all qualified hitters.
• Jac Caglianone has collected 134 hits, a team-high for the Royals.
• Salvador Perez has 23 doubles, a triple, 19 home runs and 23 walks while batting .229.

Astros vs Royals Head to Head

• 9/16/2026: 5-2 KC (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 9/15/2026: 4-2 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 6/14/2026: 4-0 KC (Favorite: Royals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 6/13/2026: 8-7 HOU (Favorite: Royals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/12/2026: 10-8 HOU (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/14/2025: 4-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/13/2025: 2-1 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 5/12/2025: 7-5 KC (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/27/2025: 7-3 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/26/2025: 2-0 KC (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)

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