Astros vs Royals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 15

Odds updated as of 2:12 a.m.

MLB action on Tuesday includes the Houston Astros facing the Kansas City Royals.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's everything you need to know.

Astros vs Royals Game Info

• Houston Astros (75-75) vs. Kansas City Royals (66-84)
• Date: Tuesday, September 15, 2026
• Time: 8:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and Royals.TV

Astros vs Royals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-162) | KC: (+136)
• Spread: HOU: -1.5 (+138) | KC: +1.5 (-166)
• Total: 7.5 -- Over: (-134) | Under: (+110)

Astros vs Royals Probable Starting Pitchers

Probable Pitchers: Hunter Brown (Astros) - 5-3, 3.52 ERA vs Michael Wacha (Royals) - 9-8, 3.25 ERA

This contest's pitching matchup is set, as the Astros will send Hunter Brown (5-3) to the mound, while Michael Wacha (9-8) will take the ball for the Royals. When Brown starts, his team is 8-9-0 against the spread this season. Brown's team has a record of 7-7 this season when he starts and they are the favorite on the moneyline. The Royals have a 15-12-0 record against the spread in Wacha's starts. The Royals have been the underdog on the moneyline in 15 of Wacha's starts this season, and they went 4-11 in those games.

Astros vs Royals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (57.8%)

Astros vs Royals Moneyline

• Kansas City is a +136 underdog on the moneyline, while Houston is a -162 favorite at home.

Astros vs Royals Spread

• The Astros are 1.5-run home favorites on the runline against the Royals. The Astros are +138 to cover, and the Royals are -166.

Astros vs Royals Over/Under

• Astros versus Royals, on Sept. 15, has an over/under of 7.5, with the over being -134 and the under +110.

Bet on Houston Astros vs. Kansas City Royals on FanDuel today!

Astros vs Royals Betting Trends

• The Astros have been favorites in 63 games this season and have come away with the win 33 times (52.4%) in those contests.
• Houston has a record of 6-9 in contests when oddsmakers favor them by -162 or more on the moneyline.
• The Astros and their opponents have hit the over in 75 of their 150 games with a total set by oddsmakers this season.
• In 150 games with a line this season, the Astros have a mark of 75-75-0 against the spread.
• The Royals have been the moneyline underdog 92 total times this season. They've gone 37-55 in those games.
• Kansas City has gone 7-15 in games it has played as a moneyline underdog with odds of +136 or longer (31.8%).
• The Royals have played in 143 games with an over/under set, and have combined with opponents to go over the total 65 times (65-75-3).
• The Royals have covered 51.7% of their games this season, going 74-69-0 against the spread.

Astros Player Leaders

• Yordan Alvarez has 162 hits and an OBP of .427 to go with a slugging percentage of .589. All three of those stats are best among Houston hitters this season. He has a .310 batting average, as well.
• Among all qualified hitters in baseball, his batting average ranks second, his on-base percentage ranks first, and he is first in slugging.
• Isaac Paredes has 26 doubles, a triple, 21 home runs and 64 walks. He's batting .260 and slugging .435 with an on-base percentage of .359.
• His batting average ranks 64th among qualified players, his on-base percentage 32nd, and his slugging percentage 60th.
• Paredes takes a six-game streak with at least one hit into this one. In his last 10 games he is batting .306 with three doubles, three home runs, four walks and 11 RBIs.
• Christian Walker has collected 119 base hits, an OBP of .299 and a slugging percentage of .417 this season.
• Jose Altuve is batting .245 with a .306 OBP and 44 RBI for Houston this season.

Royals Player Leaders

• Bobby Witt Jr. has put up an on-base percentage of .360 and a slugging percentage of .448. Both lead the Royals. He's batting .280.
• Including all qualifying hitters, he is 25th in batting average, while his on-base percentage ranks 31st and he is 47th in slugging.
• Jac Caglianone's 134 hits lead his team. He has a batting average of .281 while slugging .491 with an on-base percentage of .331.
• Including all qualified hitters, his batting average puts him 22nd, his on-base percentage is 66th, and he is 20th in slugging.
• Carter Jensen is batting .232 with 31 doubles, two triples, 24 home runs and 62 walks.
• Salvador Perez is hitting .229 with 23 doubles, a triple, 19 home runs and 23 walks.

Astros vs Royals Head to Head

• 6/14/2026: 4-0 KC (Favorite: Royals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 6/13/2026: 8-7 HOU (Favorite: Royals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/12/2026: 10-8 HOU (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/14/2025: 4-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/13/2025: 2-1 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 5/12/2025: 7-5 KC (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/27/2025: 7-3 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/26/2025: 2-0 KC (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/25/2025: 2-0 KC (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/1/2024: 7-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -158, Underdog Moneyline: +134)

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