76ers vs. Pistons Prediction, Odds, Picks, Best Bets for Oct. 25

76ers vs. Pistons Game Info

• Date: Sunday, October 25, 2026
• Time: 7:30 p.m. ET
• Venue: Xfinity Mobile Arena -- Philadelphia, Pennsylvania
• Coverage: NBCS-PH, PCK-PHI, WMYD, and DAZN-DET

The Philadelphia 76ers (3-0) are 3.5-point favorites as they attempt to continue a three-game winning streak when they host the Detroit Pistons (2-0) on Sunday, October 25, 2026 at Xfinity Mobile Arena. The contest airs at 7:30 p.m. ET on NBCS-PH, PCK-PHI, WMYD, and DAZN-DET. The point total in the matchup is set at 226.5.

76ers vs. Pistons Odds & Spread

All NBA betting lines, odds and prop bets are from FanDuel Sportsbook.

76ers vs. Pistons Prediction & Pick

All NBA win probability predictions and picks are according to numberFire.
Prediction: Pistons win (70.2%)

76ers vs. Pistons Betting Trends

• The 76ers put together a 40-40-2 ATS record last year.
• The Pistons had an ATS record of 6-0 as underdogs of 3.5 points or greater last year.
• The 76ers and their opponents combined to go over the point total 41 out of 82 times last season.
• Last season, 40 of the Pistons' 82 games hit the over.
• Philadelphia did a better job covering the spread when playing on the road (22-18-1) than it did in home games (18-22-1) last season.
• Against the spread last season, Detroit had better results on the road (23-16-1) than at home (21-19-1).

76ers Leaders

• Tyrese Maxey put up 28.3 points, 4.1 boards and 6.6 assists last year.
• Last season, Jaylen Brown recorded an average of 28.7 points, 6.9 boards and 5.1 assists per game.
• LeBron James put up 20.9 points, 6.1 rebounds and 7.2 assists. He drained 51.5% of his shots from the floor and 31.7% from beyond the arc, with 1.3 triples per contest.
• VJ Edgecombe averaged 16.0 points, 5.6 rebounds and 4.2 assists. He made 43.8% of his shots from the field and 35.4% from beyond the arc, with 2.0 treys per game.
• Joel Embiid's stats last season included 26.9 points, 7.7 rebounds and 3.9 assists per contest. He sank 48.9% of his shots from the field and 33.3% from beyond the arc, with an average of 1.4 triples.

Pistons Leaders

• Cade Cunningham collected 23.9 points last season, plus 9.9 assists and 5.5 boards.
• Jalen Duren collected 19.5 points last season, plus 2.0 assists and 10.5 boards.
• Ausar Thompson posted 9.9 points, 3.1 assists and 5.7 boards.
• John Collins posted 13.6 points, 5.3 rebounds and 1.0 assists.
• Duncan Robinson recorded 12.2 points, 2.7 rebounds and 2.1 assists, shooting 45.6% from the field and 41.0% from downtown, with 2.9 made treys per game.

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