49ers vs Cowboys Prediction, 4 Best NFL Bets, Player Props, and Odds Today, Sunday Nov 15

49ers vs Cowboys: Best Bets, Prediction, Player Props, and Odds

• Dallas Cowboys +4.5
• Over 55.5
• Javonte Williams Anytime Touchdown
• Deebo Samuel 20+ Yard Reception

49ers at Cowboys is a Sunday afternoon NFC showdown in Dallas, with the home team a 4.5-point underdog and the total sitting at 55.5. The 49ers are at -225 on the moneyline, and the Cowboys are at +188. Christian McCaffrey and Javonte Williams have both logged double-digit scrimmage touchdowns this season, and CeeDee Lamb ranks among the league's top receivers in receiving yards.

All NFL odds come from FanDuel Sportsbook's NFL betting odds and may change after this article is published.

Best Bets for 49ers vs Cowboys

San Francisco 49ers at Dallas Cowboys (Sun, 4:26 p.m. ET)

Dallas Cowboys +4.5 (-110)

Dallas is getting more than a field goal at home, and the spread is a reasonable price for a team that can score in bunches. George Pickens is back off the injury report, which gives the Cowboys a second big-play receiver to pair with Lamb. The 49ers are the better team on paper, but a 4.5-point cushion gives Dallas a realistic path to keeping this within a touchdown.

Over 55.5 (-115)

One of the higher totals on Sunday's afternoon board, and it reflects two offenses built to score. McCaffrey and Williams have been finding the end zone regularly, and Dallas's receiving corps gives Dak Prescott and the Cowboys multiple ways to move the chains.

Best Player Prop Bets for 49ers vs Cowboys

Javonte Williams Anytime Touchdown (-165)

Williams is Dallas's primary back and the featured piece of the site's own parlay for this game. He has found the end zone in most of his recent games, including a rushing touchdown in a home game, and his price reflects a strong chance to score against a 49ers defense that has to stop the run.

Deebo Samuel 20+ Yard Reception (+115)

Samuel is one of the 49ers' most targeted pass-catchers while George Kittle's status is uncertain, which increases his role in the passing game. A plus-money price on a 20-yard catch offers real value if San Francisco has to throw more than usual on the road.

Player Props to Watch

CeeDee Lamb's 20+ yard reception price is -370, a steep number for a receiver who has been among the league's most productive this season. George Pickens is priced at -210 for a 20-yard catch, a more reasonable price now that he is off the injury report. George Kittle's 15-yard reception price is -550, but he has been listed as questionable with a hamstring or foot issue, so check the final report before betting him. Christian McCaffrey's anytime touchdown price is -270, which is short for a back who has been finding the end zone regularly.

49ers vs Cowboys Prediction

San Francisco is the stronger team on paper, but Dallas has the home field and a high-scoring offense that can keep pace. Expect a shootout in which both sides trade scores, with Dallas staying within a touchdown and the total landing over 55.5. The Cowboys' home field and their balanced attack give them the edge in covering.

Odds at a Glance

Spread: Dallas +4.5 (-110), San Francisco -4.5 (-110). Moneyline: San Francisco -225, Dallas +188. Total: Over 55.5 (-115), Under 55.5 (-105). Anytime touchdown prices: Christian McCaffrey -270, Javonte Williams -165, CeeDee Lamb -110, George Kittle +120, George Pickens +175.