3 Best MLB Bets, Player Props, and Home Run Picks for Saturday 4/26/25

In a given MLB slate, you've got tons of markets to dig through, from totals to home runs and strikeout props.

Which bets stand out for today's games?

Below, I'm going to run through my favorite bets in FanDuel Sportsbook's MLB betting odds. You can get additional insights from our daily MLB player prop projections.

Note: Lines are subject to change throughout the day after this article is published. All stats come from FanGraphs and Baseball Savant unless noted otherwise.

Today's Best MLB Bets, Player Props, and Home Run Picks

Philadelphia Phillies at Chicago Cubs

Jesus Luzardo Under 5.5 Strikeouts (-120)

It's a tough matchup for Jesus Luzardo to pile up Ks today.

There's a bit of concern that the Philadelphia Phillies and Chicago Cubs' low game total (7.0) could lead to a longer game outing for Luzardo, but the Cubbies just don't whiff against lefties. They've got the league's second-lowest strikeout rate (17.6%) against them so far.

Luzardo's slightly outperformed his 14.1% swinging-strike rate to post 10.7 K/9 thus far, too.

FanDuel Research's MLB player prop projections expect just 5.0 strikeouts in 5.51 median innings for Luzardo on Saturday. We'd have expected to see closer to -160 on this line.

Boston Red Sox at Cleveland Guardians

Red Sox Moneyline (-106)

How about a rare two-game weekend set in "The Land"? The Boston Red Sox and Cleveland Guardians had a rare Friday off yesterday.

I like the BoSox to win the opener. They've got an improving Walker Buehler toeing the slab. Buehler's 3.57 skill-interactive ERA (SIERA) is much better than his actual (4.23) at the moment, which is a product of an elevated groundball rate (47.2%) and low hard-contact rate (32.9%). He's also reduced his BB% to just 7.0%.

Cleveland counters with an MLB debut for Doug Nikhazy, who had a 4.42 xFIP in the minors last season.

Considering Boston (.726 team OPS against RHP) has been a bit ahead of the Guards (.702) as an offense in this split, I'll take the known commodity as a slight 'dog.

Pittsburgh Pirates at Los Angeles Dodgers

Andrew McCutchen to Hit a Home Run (+560)

Roki Sasaki's growing pains have been real.

Sasaki's 5.83 SIERA has featured a mediocre flyball (37.0%) and poor hard-hit (44.4%) rate allowed, but he's been a bit fortunate to allow just 0.92 HR/9 despite home games at MLB's third-friendliest venue for home runs -- like the one tonight.

There are several Los Angeles Dodgers short for a bomb, but how about old man Andrew McCutchen in a throwback season for the Pittsburgh Pirates at this stage? McCutchen has posted a .740 OPS, .178 ISO, 47.1% hard-hit rate, and 38.2% flyball rate against righties thus far.

Our projections expect 0.25 home runs from McCutchen, who is projected to hit third, on Saturday. That would imply odds closer to +352 odds for a bomb if correct.

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The above author is a FanDuel employee and is not eligible to compete in public daily fantasy contests or place sports betting wagers on FanDuel. The advice provided by the author does not necessarily represent the views of FanDuel. Taking the author's advice will not guarantee a successful outcome. You should use your own judgment when participating in daily fantasy contests or placing sports wagers.