Notre Dame vs USC Prediction, Odds & Best Bet for Week 13 (Trojans Too Tough for Irish)

Notre Dame vs USC Week 13 Game Info

2022 NCAA College Football Game
No. 15 Notre Dame Fighting Irish (8-3) vs. No. 6 USC Trojans (10-1)
Date: Saturday, Nov. 26, 2022
Time: 7:30 p.m. ET
Venue: LA Memorial Coliseum — Los Angeles, CA
Coverage: ABC

Week 13 of the 2022 NCAA college football season includes Top 25 matchup between the No. 15 Notre Dame Fighting Irish and No. 6 USC Trojans. Southern Cal is still in consideration for a CFB Playoff spot if they beat Notre Dame here and win next week's Pac-12 Championship Game.

Notre Dame vs USC Odds & Spread

All NCAAF betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: ND: (+155) | USC: (-188)
Spread: ND: +4.5 (-110) | USC: -4.5 (-110)
Total: 64.5 — Over: (-108) | Under: (-112)

USC enters this game as a solid home favorite on both the spread and moneyline. The total is more than a TD higher than an average CFB total and currently sits at 64.5 points -- up 2 points from the opening line last Sunday.

Notre Dame vs USC Prediction & Pick

USC coach Lincoln Riley's fine-tuned Trojans offense is led by the new Heisman favorite QB Caleb Williams. The Trojans' elite offense (513 YPG, 7.1 yards per play) ranks No. 2 in the country but gets a tougher test this week against the Fighting Irish defense. Still, USC has outscored opponents by an average margin of 16.6 points and has the home-field advantage here as well.

Southern Cal's defense forced 3 interceptions last week against UCLA and now leads the country with a +20 turnover margin. Notre Dame will try to run the ball more and control the clock, but that may not be enough to keep up with USC's more potent offense.

At some point, Irish QB Drew Pyne will have to make some big plays in the passing game. His 1,703 passing yards and 61.8% completion percentage don't suggest he can do enough to keep pace with the Trojans' high-powered attack.

Final Score Prediction: USC: 37 | Notre Dame: 24

Notre Dame vs USC Betting Trends

- Notre Dame is 5-0 straight up (SU) in their last 5 games.
- Notre Dame is 6-0 SU in their last 6 road games.
- The total has gone Over in each of Notre Dame's last 5 games.
- USC is 10-1 SU in their last 11 games.
- USC is 4-2 ATS in their last 6 games.
- The total has hit the Over in each of USC's last 5 games.

Notre Dame vs USC Best Bet

All NCAAF betting lines, odds and prop bets are available on FanDuel Sportsbook.

Desperately hanging on to beat rival UCLA last week sets up a potential letdown spot for the Trojans. But with Williams under center for USC and the Trojans scoring at least 41 points in five straight games, we'll bet on the player and the superior offense to win and continue their strong play at home.

Bet: USC -4.5 (-110)

Game odds refresh periodically and are subject to change.