Yankees vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for April 23

Odds updated as of 12:12 p.m.

The MLB slate on Wednesday includes the New York Yankees taking on the Cleveland Guardians.

We've got you covered, in terms of the most important info about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Yankees vs Guardians Game Info

• New York Yankees (14-10) vs. Cleveland Guardians (14-9)
• Date: Wednesday, April 23, 2025
• Time: 1:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CLEG and YES

Yankees vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: NYY: (-164) | CLE: (+138)
• Spread: NYY: -1.5 (-104) | CLE: +1.5 (-115)
• Total: 8.5 -- Over: (-100) | Under: (-122)

Yankees vs Guardians Probable Starting Pitchers

Probable Pitchers: Carlos Rodón (Yankees) - 2-3, 4.34 ERA vs Luis Ortiz (Guardians) - 2-2, 5.48 ERA

The probable starters are Carlos Rodon (2-3) for the Yankees and Luis Ortiz (2-2) for the Guardians. Rodon's team is 1-4-0 against the spread in his starts this season. Rodon's team is 2-3 this season when he starts and they are the moneyline favorite. The Guardians have gone 2-2-0 against the spread when Ortiz starts. The Guardians were named the moneyline underdog for one Ortiz start this season -- they lost.

Yankees vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Yankees win (52%)

Yankees vs Guardians Moneyline

• New York is a -164 favorite on the moneyline, while Cleveland is a +138 underdog at home.

Yankees vs Guardians Spread

• The Yankees are at the Guardians and are favored by 1.5 runs on the spread. The Yankees are -104 to cover the runline, with the Guardians being -115.

Yankees vs Guardians Over/Under

• An over/under of 8.5 has been set for Yankees-Guardians on April 23, with the over being -100 and the under -122.

Bet on New York Yankees vs. Cleveland Guardians on FanDuel today!

Yankees vs Guardians Betting Trends

• The Yankees have been chosen as favorites in 19 games this year and have walked away with the win 13 times (68.4%) in those games.
• New York has a record of 4-1 when favored by -164 or more this year.
• Contests with the Yankees have gone over the total set by bookmakers in 12 of 24 chances this season.
• The Yankees have an against the spread record of 11-13-0 in 24 games with a line this season.
• The Guardians have won six of the 13 games they were listed as the moneyline underdog this season (46.2%).
• When playing as a moneyline underdog with odds of +138 or longer, Cleveland has a 2-2 record (winning 50% of its games).
• The Guardians have played in 23 games with a set over/under, and have combined with opponents to go over the total 12 times (12-10-1).
• The Guardians are 11-12-0 against the spread this season.

Yankees Player Leaders

• Aaron Judge leads New York in OBP (.509), slugging percentage (.722) and total hits (37) this season. He has a .411 batting average.
• Among qualifying hitters in the majors, he ranks first in batting average, first in on-base percentage, and first in slugging.
• Judge has recorded a base hit in four games in a row. In his last five games he is batting .450 with two doubles, two walks and three RBI.
• Ben Rice is hitting .286 with three doubles, a triple, six home runs and 10 walks. He's slugging .614 with an on-base percentage of .390.
• His batting average ranks 46th among qualified players, his on-base percentage 26th, and his slugging percentage eighth.
• Paul Goldschmidt is batting .371 with a .461 slugging percentage and seven RBI this year.
• Goldschmidt has logged a hit or more in seven games in a row. In his last 10 outings he is hitting .389 with a double, five walks and two RBI.
• Anthony Volpe is batting .209 with a .310 OBP and 15 RBI for New York this season.

Guardians Player Leaders

• Steven Kwan has accumulated a team-high OBP (.400) and slugging percentage (.505). He's batting .341.
• Including all qualifying hitters, he ranks ninth in batting average, while his on-base percentage is 19th and he is 32nd in slugging.
• Kwan takes a six-game hitting streak into this matchup. In his last 10 outings he is batting .341 with two doubles, two home runs, four walks and six RBI.
• Jose Ramirez has four doubles, five home runs and eight walks while batting .263. He's slugging .500 with an on-base percentage of .323.
• Including all qualifying players, he ranks 73rd in batting average, 91st in on-base percentage and 34th in slugging percentage.
• Kyle Manzardo has racked up 16 hits, a team-high for the Guardians.
• Gabriel Arias is hitting .271 with three doubles, four home runs and five walks.

Yankees vs Guardians Head to Head

• 4/22/2025: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/21/2025: 6-4 CLE (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 10/19/2024: 5-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 10/18/2024: 8-6 NYY (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 10/17/2024: 7-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 10/15/2024: 6-3 NYY (Favorite: Yankees, Spread: -1.5, Total: 7, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 10/14/2024: 5-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 8/22/2024: 6-0 NYY (Favorite: Yankees, Spread: -1.5, Total: 8, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 8/21/2024: 8-1 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 8/20/2024: 9-5 CLE (Favorite: Yankees, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)

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