White Sox vs Twins Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 6

Odds updated as of 1:12 a.m.

The Chicago White Sox will take on the Minnesota Twins in MLB action on Sunday.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

White Sox vs Twins Game Info

• Chicago White Sox (74-68) vs. Minnesota Twins (68-74)
• Date: Sunday, September 6, 2026
• Time: 6:20 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: NBCSN and Peacock

White Sox vs Twins Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHW: (-146) | MIN: (+124)
• Spread: CHW: -1.5 (+150) | MIN: +1.5 (-182)
• Total: 8.5 -- Over: (+100) | Under: (-122)

White Sox vs Twins Probable Starting Pitchers

Probable Pitchers: Bryan Hudson (White Sox) - 4-4, 3.03 ERA vs Bailey Ober (Twins) - 7-4, 4.37 ERA

The probable starters are Bryan Hudson (4-4) for the White Sox and Bailey Ober (7-4) for the Twins. Hudson and his team have a record of 5-2-0 against the spread when he starts. Hudson's team has won 66.7% of his starts when they are favored on the moneyline (2-1). The Twins have a 12-8-0 ATS record in Ober's 20 starts that had a set spread. The Twins are 8-5 in Ober's 13 starts this season that they were the underdog on the moneyline.

White Sox vs Twins Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: White Sox win (55.2%)

White Sox vs Twins Moneyline

• Looking at the moneyline for Twins-White Sox, Minnesota is the underdog at +124, and Chicago is -146 playing at home.

White Sox vs Twins Spread

• The White Sox are hosting the Twins and are favored by 1.5 runs (+150 to cover) on the runline. Minnesota is -182 to cover.

White Sox vs Twins Over/Under

• The over/under for White Sox-Twins on Sept. 6 is 8.5. The over is +100, and the under is -122.

Bet on Chicago White Sox vs. Minnesota Twins on FanDuel today!

White Sox vs Twins Betting Trends

• The White Sox have won in 18, or 58.1%, of the 31 contests they have been named as odds-on favorites in this year.
• Chicago has a record of 3-1 when favored by -146 or more this year.
• The White Sox and their opponents have hit the over in 76 of their 139 games with a total set by oddsmakers this season.
• The White Sox have posted a record of 80-59-0 against the spread this season.
• The Twins have gone 37-46 in games they were the underdog on the moneyline (winning 44.6% of those games).
• Minnesota has a record of 15-19 in games it has played as a moneyline underdog with odds of +124 or longer (44.1%).
• In the 139 games oddsmakers have set an over/under for the Twins, they have combined with opponents to go over the total 78 times (78-58-3).
• The Twins have collected a 75-64-0 record against the spread this season (covering 54% of the time).

White Sox Player Leaders

• Miguel Vargas leads Chicago with 130 hits, batting .251 this season with 61 extra-base hits. He has an on-base percentage of .362 and a slugging percentage of .486.
• Among qualifying hitters in baseball, he is 75th in batting average, 25th in on-base percentage, and 19th in slugging.
• Vargas hopes to build on a three-game hitting streak in this matchup. In his last five games he is hitting .300 with a home run, a walk and two RBIs.
• Chase Meidroth has hit 12 homers this season while driving in 51 runs. He's batting .271 this season and slugging .396 with an on-base percentage of .343.
• Among qualified hitters, his batting average places him 40th, his on-base percentage 48th, and his slugging percentage 94th.
• Sam Antonacci has 110 hits this season and a team-best OBP of .364.
• Tristan Peters has 12 home runs, 52 RBI and a batting average of .281 this season.
• Peters takes a two-game hitting streak into this game. During his last five outings he is batting .333 with a double, a triple and a walk.

Twins Player Leaders

• Brooks Lee has 22 doubles, three triples, 22 home runs and 33 walks while batting .248. He's slugging .432 with an on-base percentage of .296.
• Including all qualifying hitters in MLB, he ranks 82nd in batting average, 123rd in on-base percentage and 59th in slugging percentage.
• Josh Bell is slugging .427 to pace his team. He has a batting average of .259 with an on-base percentage of .323.
• Including all qualified hitters, his batting average puts him 64th, his on-base percentage is 83rd, and he is 64th in slugging.
• Kody Clemens has put up 110 hits, a team-best for the Twins.
• Luke Keaschall leads his team with a .366 on-base percentage.

White Sox vs Twins Head to Head

• 9/5/2026: 6-4 MIN (Favorite: White Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 9/4/2026: 4-1 CHW (Favorite: White Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/30/2026: 5-1 MIN (Favorite: Twins, Spread: -1.5, Total: 9, Favorite Moneyline: -114, Underdog Moneyline: +104)
• 8/29/2026: 3-2 CHW (Favorite: Twins, Spread: -1.5, Total: 9, Favorite Moneyline: -110, Underdog Moneyline: +100)
• 8/28/2026: 7-4 CHW (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +116)
• 6/3/2026: 8-0 CHW (Favorite: Twins, Spread: -1.5, Total: 9, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 6/2/2026: 6-4 MIN (Favorite: White Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 6/1/2026: 9-6 MIN (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 5/28/2026: 6-2 CHW (Favorite: White Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 5/27/2026: 15-2 CHW (Favorite: White Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -108, Underdog Moneyline: -108)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!