Week 17 NFL Odds: Predictions, Spreads, Moneylines, and Totals for Every Game

The Week 17 NFL slate is absent of a Monday game, but we've got a primetime matchup on Saturday to make up for it.

Here are the NFL betting odds for each game in Week 17. All game predictions via numberFire.

Lions at Cowboys Week 17 Odds

• Detroit Lions Moneyline: +220
• Dallas Cowboys Moneyline: -270
• Spread: Cowboys (-5.5)
• Total: 52.5
• numberFire Prediction: Cowboys (67.7%)

While we don't have a Monday Night Football game, we've got an MNF-caliber matchup on Saturday night between the Lions and Cowboys.

Dallas enters this one with an unblemished 7-0 home record and a league-best 39.9 points per game at home mark.

Detroit's 6-2 road record is tied to a -4 point differential.

Dallas is moderately favored over the Lions, and the spread (plus the total) has grown in their favor since the weekend.

Dolphins at Ravens Week 17 Odds

• Miami Dolphins Moneyline: +144
• Baltimore Ravens Moneyline: -172
• Spread: Ravens (-3.5)
• Total: 46.5
• numberFire Prediction: Ravens (55.0%)

Miami's offense has traveled well this season (27.1 points per game, second-best in the NFL), yet they have only a 4-3 record away from home.

Baltimore is on a short week after facing the 49ers on Monday Night Football to close out the Christmas Day slate of games. They got the better of the 49ers in a battle between the 1 seeds in each conference entering the week.

The Ravens are 5-2 at home with a dominant +13.9 point differential in those matchups.

Key injuries to monitor here include Jaylden Waddle (ankle; out) and Raheem Mostert (knee/ankle; questionable) for the Dolphins and Zay Flowers (calf; questionable) for the Ravens.

Patriots at Bills Week 17 Odds

• New England Patriots Moneyline: +660
• Buffalo Bills Moneyline: -950
• Spread: Bills (-14)
• Total: 40.5
• numberFire Prediction: Bills (87.7%)

The Bills will be looking for revenge on the Patriots, who scored an upset win back in Week 7 by a score of 29-25.

New England out-gained Buffalo 364-339 in that game and went 4 of 9 on third-down conversion attempts.

New England's faltering has them out of the playoffs and in the hunt for the top overall draft pick. However, they're still fighting and beat the Broncos in Week 16 on Sunday Night Football.

Meanwhile, the Bills are doing all they can to stay alive in the playoff race amidst a three-game win streak.

Falcons at Bears Week 17 Odds

• Atlanta Falcons Moneyline: +128
• Chicago Bears Moneyline: -152
• Spread: Bears (-2.5)
• Total: 37.5
• numberFire Prediction: Bears (54.1%)

The Falcons can look back at their road performance this season (2-5 record and a -4.4 point differential) to find missed opportunities.

The team turned the offense back over to Taylor Heinicke in Week 16 in hopes to close out the season strong. Heinicke threw for 229 yards on 33 attempts with a touchdown in their win over Indianapolis.

Chicago is a standard home favorite in a game that has low-level playoff implications.

Titans at Texans Week 17 Odds

• Tennessee Titans Moneyline: +172
• Houston Texans Moneyline: -205
• Spread: Texans (-4.5)
• Total: 43.5
• numberFire Prediction: Texans (63.7%)

We just saw this matchup in Week 15, a game that resulted in a 19-16 overtime win by the Texans during a start by Case Keenum, who threw for 229 yards.

The Texans' offense, though, ran through Devin Singletary, who ran for 121 yards and caught 4 passes for 49 yards.

With the Titans' playoff hopes dashed, they remain road underdogs in Week 17.

CJ Stroud has cleared concussion protocol and has no injury designation for this week.

Raiders at Colts Week 17 Odds

• Las Vegas Raiders Moneyline: +148
• Indianapolis Colts Moneyline: -176
• Spread: Colts (-3.5)
• Total: 42.5
• numberFire Prediction: Raiders (50.3%)

The Colts are coming off an impactful Week 16 loss agains the Falcons, but Week 17 matters plenty for them still.

Indianapolis holds merely a 3-4 home record and a +0.4 point differential per game in those seven matchups at Lucas Oil Stadium.

They're favored in a game with a total in the low 40s over a Raiders team that scored an upset win over the Chiefs on Christmas Day in order to stay alive in the playoff race with their 7-8 record.

Michael Pittman Jr. (concussion/shoulder) returned to a full practice Friday and is listed as questionable.

Rams at Giants Week 17 Odds

• Los Angeles Rams Moneyline: -255
• New York Giants Moneyline: +210
• Spread: Rams (-6)
• Total: 43.5
• numberFire Prediction: Rams (73.7%)

The Rams set the tone early in Week 16 with a Thursday Night Football win over the Saints by a final score of 30-22. They led 17-7 at the half and eventually led 30-7 before New Orleans closed the gap a bit.

They are now 8-7 on the season just in time for a matchup against the Giants, who are on a short week after a Christmas Day game against the Eagles.

New York has a bottom-three point differential at home (-8.7), and they benched QB Tommy DeVito in favor of Tyrod Taylor in Week 16. Taylor will start Week 17.

49ers at Commanders Week 17 Odds

• San Francisco 49ers Moneyline: -950
• Washington Commanders Moneyline: +640
• Spread: 49ers (-14)
• Total: 49.5
• numberFire Prediction: 49ers (76.0%)

The 49ers are the only team in the league to average more than 30 points per game in road matchups (30.8), and in their eight road games, they're 6-2.

They'll be looking to bounce back after a big loss to the Ravens in Week 16 on Monday Night Football.

Washington, at home, is a dreadful 1-5, and they've averaged only 18.0 points per game at FedExField.

The 49ers, again, are double-digit favorites.

Panthers at Jaguars Week 17 Odds

• Carolina Panthers Moneyline: +180
• Jacksonville Jaguars Moneyline: -215
• Spread: Jaguars (-3.5)
• Total: 36.5
• numberFire Prediction: Jaguars (63.7%)

The Jaguars have played at home and at Tampa Bay the past two weeks, so they're in Florida for a third straight matchup, this one against the Carolina Panthers.

Despite that, they've dropped four straight games overall, and Jacksonville is only 3-5 at home. Their point differential at EverBank Stadium is only -5.9 per game, as well.

Carolina, though, has a league-worst point differential in road matchups (-12.9).

Understandably, the expectation is a Jaguars win based on the spread even with the Panthers playing well as of late.

The spread dropped significantly with news that Trevor Lawrence will be out.

Cardinals at Eagles Week 17 Odds

• Arizona Cardinals Moneyline: +460
• Philadelphia Eagles Moneyline: -620
• Spread: Eagles (-11.5)
• Total: 48
• numberFire Prediction: Eagles (77.6%)

In a battle of the birds, the Eagles are big favorites over the Arizona Cardinals, who are eliminated from playoff contention and are vying for the top overall pick in the NFL Draft.

The Eagles, meanwhile, are reeling themselves (although their 10-1 start has given them a lot of room to work with as the season winds down before their losing streak kicked in).

They'll be on a short week after playing the Giants on Christmas Day and surviving with a 33-25 win.

Saints at Buccaneers Week 17 Odds

• New Orleans Saints Moneyline: +118
• Tampa Bay Buccaneers Moneyline: -138
• Spread: Buccaneers (-2.5)
• Total: 42.5
• numberFire Prediction: Buccaneers (55.9%)

While the Saints made Thursday Night Football a one-score game, they trailed 30-7 in the second half before scoring 15 unanswered points to fall to 7-8 on the year.

Thanks to the weak nature of the NFC South, they still have a shot at the playoffs by way of a division crown.

Back in Week 4, the Buccaneers won this matchup 26-9 in New Orleans and limited Derek Carr to 127 yards on 37 attempts.

Baker Mayfield racked up 246 yards and 3 touchdowns on his 32 attempts.

Tampa Bay has won four straight.

Steelers at Seahawks Week 17 Odds

• Pittsburgh Steelers Moneyline: +150
• Seattle Seahawks Moneyline: -178
• Spread: Seahawks (-3.5)
• Total: 41.5
• numberFire Prediction: Seahawks (54.2%)

The Steelers' playoff homes tanked pretty quickly down the stretch, and they were unable to maintain an elite one-score game record through the end of the season.

They're 3-3 on the road even with a -4.3 point differential average in those matchups. A 34-11 win over the Bengals, though, has them alive in the playoff hunt.

Seattle's Week 16 matchup with the Titans (a 20-17 win) could prove crucial in their ultimate playoff fate.

The Seahawks are 5-2 at home despite a point differential of -5.

Bengals at Chiefs Week 17 Odds

• Cincinnati Bengals Moneyline: +240
• Kansas City Chiefs Moneyline: -295
• Spread: Chiefs (-6.5)
• Total: 43.5
• numberFire Prediction: Chiefs (73.3%)

Kansas City heads into Week 17 as big home favorites over the Bengals even after losing at home to the Raiders on Christmas Day.

Patrick Mahomes has been held under 300 yards in seven of his past eight games and is averaging 6.9 yards per attempt on the season.

The Bengals were drubbed 34-11 on Saturday by the Steelers and currently hold the 10 seed in the AFC.

Isiah Pacheco (concussion/shoulder) is questionable after a limited practice on Friday; Clyde Edwards-Helaire is also questionable with an illness.

For the Bengals, Ja'Marr Chase (shoulder) is also questionable after limited practices on Thursday and Friday.

Chargers at Broncos Week 17 Odds

• Los Angeles Chargers Moneyline: +152
• Denver Broncos Moneyline: -180
• Spread: Broncos (-3.5)
• Total: 38.5
• numberFire Prediction: Broncos (62.7%)

The first matchup between these AFC West rivals came in Week 14, which was a 24-7 win by Denver on the road.

In that game, Justin Herbert was injured, and Easton Stick was able to churn out 179 yards on 24 attempts in relief.

But the Broncos controlled the clock (33:29 of possession) by running 31 times.

Denver has played well down the stretch but have now lost two straight and three of their past four, including a 26-23 loss to New England on Sunday Night Football in Week 16.

Denver is moving on from Russell Wilson and will start Jarrett Stidham at quarterback.

Packers at Vikings Week 17 Odds

• Green Bay Packers Moneyline: -102
• Minnesota Vikings Moneyline: -116
• Spread: Vikings (-1.5)
• Total: 43.5
• numberFire Prediction: Vikings (53.9%)

In Kirk Cousins' final game of the season, the Vikings went into Lambeau Field and beat the Packers 24-10.

Minnesota held Jordan Love to just 229 yards on 41 attempts and the Packers to just 5 third-down conversions on 14 attempts.

Now, they're slight favorites with Jaren Hall under center against a Packers team that just beat the Panthers 33-30.

With both teams at 7-8, this game has massive wild card implications.

Vikings TE T.J. Hockenson is out for the season with a torn ACL and MCL. The Packers suspended CB Jaire Alexander for this week's game.

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