Week 16 NFL Odds: Predictions, Spreads, Moneylines, and Totals for Every Saturday Game

This weekend, 16 NFL games span four days, and a lot of playoff positioning is up for grabs.

Saturday's matchups are quite distinct from one another. One is a tight spread between division foes, and the other is a double-digit spread between teams trending in very opposite directions.

Here are the NFL betting odds for each game in Week 16 on Saturday. All game predictions via numberFire.

Bengals at Steelers Week 16 Odds

• Cincinnati Bengals Moneyline: -152
• Pittsburgh Steelers Moneyline: +128
• Spread: Bengals (-2.5)
• Total: 37.5
• numberFire Prediction: Bengals (56.2%)

The reeling Steelers play again on Saturday, this time at 4:30 pm Eastern. They have lost three straight games and four of their past five. Mitchell Trubisky has thrown for under 200 yards in every game of extended action this season.

The Bengals, on the other hand, came from behind (trailing 17-3) to beat the Vikings 27-24 in overtime thanks to 324 yards from Jake Browning.

However, in that Week 15 game, superstar wide receiver Ja'Marr Chase sprained his AC joint. He's out this week.

The Steelers will be starting Mason Rudolph at quarterback.

Bills at Chargers Week 16 Odds

• Buffalo Bills Moneyline: -820
• Los Angeles Chargers Moneyline: +570
• Spread: Bills (-12.5)
• Total: 43.5
• numberFire Prediction: Bills (71.8%)

The Chargers will be in a consecutive primetime matchup, this one kicking off on Saturday at 8:00 pm Eastern.

The Chargers were walloped 63-21 on Thursday Night Football in Week 15 by the Raiders. Easton Stick threw for 257 yards in his start in relief of Justin Herbert. Josh Palmer had 113 yards, but the game was out of hand early.

WR Keenan Allen (heel) is out again this week.

Buffalo scored a statement win over the Cowboys in Week 15 to move to 8-6 on the season. They're just 3-6 in one-score games this season, and their +125 point differential suggests their record should be 10.1-3.9.

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The above author is a FanDuel employee and is not eligible to compete in public daily fantasy contests or place sports betting wagers on FanDuel. The advice provided by the author does not necessarily represent the views of FanDuel. Taking the author's advice will not guarantee a successful outcome. You should use your own judgment when participating in daily fantasy contests or placing sports wagers.