Week 12 NFL Odds: Spreads, Moneylines, and Totals for Every Thanksgiving Day Game

Week 12 brings with it a full 16 games and is bookended by NFC North matchups on Thursday afternoon and Monday night.

But, let's be real: it's truly headlined by the three-game Thanksgiving Day slate.

Here are the NFL betting odds for each game in Week 12 on Thanksgiving Day.

Packers at Lions Week 12 Odds

• Spread: Lions (-7.5)
• Green Bay Packers Moneyline: +295
• Detroit Lions Moneyline: -370
• Total: 45.5

Thanksgiving opens up with an NFC North rematch between the Packers and Lions. Detroit won the opening game of the series in Week 4 by a score of 34-20.

The Lions fed RB David Montgomery 32 carries, and he turned them into 121 yards and 3 touchdowns. Amon-Ra St. Brown scored but drew season lows in targets (7) and yards (56) due to the game script.

Ultimately, the Packers were out-earned 401-230 in terms of net yards in the matchup and were specifically pummeled on the ground 211 to 27.

Both teams held on to win close games in Week 11, but the spread indicates that the Lions are expected to build on their 37-44-2 all-time Thanksgiving record.

Commanders at Cowboys Week 12 Odds

• Spread: Cowboys (-10.5)
• Washington Commanders Moneyline: +420
• Dallas Cowboys Moneyline: -560
• Total: 48.5

Despite being a divisional game in Week 12, the Commanders and Cowboys haven't squared off yet. They'll face off in Week 18 in what could be a decisive game for the Cowboys' NFC East hopes.

Washington again lost to the Giants in Week 11, completing a costly series sweep as Washington is now 4-7 on the season with two of those losses coming against New York.

Dallas beat the Panthers by 23 points and look to move to 8-3 on Thanksgiving Day. Their all-time Thanksgiving record is 32-22-1.

The total is trending up.

49ers at Seahawks Week 12 Odds

• Spread: 49ers (-6.5)
• San Francisco 49ers Moneyline: -295
• Seattle Seahawks Moneyline: +240
• Total: 43.5

In a scheduling quirk, the 49ers and Seahawks have not yet faced one another (which is pretty common for divisional matchups this week), but they will actually play again quite soon: December 10th in Week 14.

Seattle succumbed to a last-second field goal in Week 11, and they suffered injuries, too. QB Geno Smith bruised his triceps but was able to return in the fourth quarter. RB Kenneth Walker sustained an oblique strain that sidelined him.

The 49ers rolled over the Buccaneers in Week 11. QB Brock Purdy posted a perfect passer rating of 158.3 in the matchup, and Christian McCaffrey started a new touchdown streak with a receiving score.

The spread is moving toward San Francisco.

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