Week 10 NFL Odds: Spreads, Moneylines, and Totals for Every Game

Some high-octane offenses are on bye in Week 10, but we still have a good amount of close spreads in store for this week of NFL action.

Here are the NFL betting odds for each game in Week 10.

Colts at Patriots Week 10 Odds

• Spread: Colts (-1.5)
• Indianapolis Colts Moneyline: -126
• New England Patriots Moneyline: +108
• Total: 43.5

Last week's game in Frankfurt wound up close, and this one is projected to stay competitive, as well.

The Colts pulled away from the Panthers in Week 9, thanks to defensive heroics from Kenny Moore, who returned two interceptions for touchdowns.

The Patriots' playoff hopes are effectively dashed, and the 2-7 squad has a -93 point differential. Only the Giants (-116) are worse in that department.

QB Mac Jones has averaged just 6.1 yards per attempt this season with 10 touchdowns and 9 interceptions.

Rhamondre Stevenson had a good showing in Week 9. The running back generated 87 rushing yards and a score in addition to 42 receiving yards in the team's loss.

49ers at Jaguars Week 10 Odds

• Spread: 49ers (-3)
• San Francisco 49ers Moneyline: -168
• Jacksonville Jaguars Moneyline: +142
• Total: 45.5

Both the 49ers and Jaguars were on bye in Week 9, and it's the 49ers who are favored on the road in this matchup despite some win and loss streaks pointing in the opposite direction.

San Francisco is 5-3 -- but have lost three straight games and are 1-2 against AFC opponents.

The Jaguars are 6-2 with five straight wins.

Notably, 49ers WR Deebo Samuel is likely to return.

Jaguars WR Zay Jones is out.

Saints at Vikings Week 10 Odds

• Spread: Saints (-3)
• New Orleans Saints Moneyline: -154
• Minnesota Vikings Moneyline: +130
• Total: 40.5

The Saints held off the Bears in Week 9 to move to 5-4 on the season. They are first in the NFC South and also have the only positive point differential (+24) in the division. They won't have a pushover win in Week 10, though.

The Vikings lost Jaren Hall (concussion) in Week 9, and Josh Dobbs entered and put on quite the show. Dobbs finished the game with 158 yards (on 30 attempts) and 2 touchdowns with 7 carries for 66 yards and a touchdown, as well.

TJ Hockenson is listed as questionable.

Titans at Buccaneers Week 10 Odds

• Spread: Buccaneers (-1.5)
• Tennessee Titans Moneyline: +100
• Tampa Bay Buccaneers Moneyline: -118
• Total: 38.5

The 3-5 Titans have done all their winning at home (3-1), meaning they're 0-4 on the road through Week 9, including a Week 9 loss in Pittsburgh.

QB Will Levis apparently didn't impress head coach Mike Vrabel, so it's unclear if he will start in Week 10 or if it will be veteran Ryan Tannehill.

WR Treyon Burks (concussion) is out.

The Buccaneers lost a fourth straight game in Week 9, this one in comeback fashion to the Texans. They're now 3-5, as well. Interestingly, they're 1-3 at home.

Their point differential (-9) is quite reasonable, so something will have to give between these two 3-5 squads.

Browns at Ravens Week 10 Odds

• Spread: Ravens (-6.5)
• Cleveland Browns Moneyline: +235
• Baltimore Ravens Moneyline: -290
• Total: 38.5

This is a rematch of a Week 4 game, a 28-3 win for the Ravens in Cleveland.

In that game, Lamar Jackson threw just 19 times for 186 yards and 2 touchdowns, and Baltimore racked up 131 rushing yards and 2 scores on 31 attempts.

Starting at quarterback for Cleveland, though, was Dorian Thompson-Robinson. DTR accrued only 121 passing yards and 3 interceptions on 36 attempts.

Deshaun Watson hasn't been the exemplar of efficiency (6.6 yards per attempt with 6 touchdowns and 3 interceptions) but is an obvious upgrade for the offense from what Baltimore saw in Week 4.

Texans at Bengals Week 10 Odds

• Spread: Bengals (-6.5)
• Houston Texans Moneyline: +205
• Cincinnati Bengals Moneyline: -250
• Total: 47

CJ Stroud and the Texans put on quite the comeback in Week 9 against the Buccaneers. Stroud set a rookie record in passing yards (470) and threw for 5 touchdowns.

Noah Brown (153), Dalton Schultz (130), and Tank Dell (114) all cleared 100 yards in the record-setting performance.

The Bengals played the Bills on Sunday Night Football in Week 9 and earned a 24-18 win.

Quarterback Joe Burrow displayed good mobility and threw for 348 yards and 2 touchdowns in the win.

For Cincinnati, WR Ja'Marr Chase (back) is questionable, and Tee Higgins (hamstring) is out.

Texans WR Nico Collins (calf) and RB Dameon Pierce (ankle) are out.

Packers at Steelers Week 10 Odds

• Spread: Steelers (-3)
• Green Bay Packers Moneyline: +152
• Pittsburgh Steelers Moneyline: -180
• Total: 38.5

The Steelers are 5-3 despite a -30 point differential, one of the 10 worst point differentials among 5-3 teams in NFL history, according to Stathead.

Quarterback Kenny Pickett is averaging only 6.5 yards per attempt and has 6 touchdowns with 4 interceptions. The good news is that he may not need to put up a lot of production for Pittsburgh to pick up a win in Week 10.

The Packers have scored 20, 10, 17, 13, 20, 18, and 24 points in their most recent games. The only game with more than 24 this year came back in Week 1 when they put up 38.

Falcons at Cardinals Week 10 Odds

• Spread: Falcons (-1.5)
• Atlanta Falcons Moneyline: -120
• Arizona Cardinals Moneyline: +102
• Total: 43.5

The Falcons lost a heartbreaking game to the Vikings in Week 9, thanks to the heroics of Josh Dobbs.

In that game, QB Taylor Heinicke accrued 268 yards on 38 attempts with a touchdown and an interception. Tight end Jonnu Smith racked up 100 yards and a score.

The Cardinals were blanked in Cleveland (27-0) in rookie quarterback Clayton Tune's debut. Tune threw only 20 times for 58 yards and 2 interceptions. Kyler Murray will return for the 1-8 Cardinals.

Lions at Chargers Week 10 Odds

• Spread: Lions (-3)
• Detroit Lions Moneyline: -158
• Los Angeles Chargers Moneyline: +134
• Total: 48.5

The Lions will get an advantageous schedule quirk in Week 10. They are coming off of a bye and are playing the Chargers, who will be on a short week after playing on Monday Night Football in Week 9.

Detroit's 6-2 record has them in first place in the NFC North. They're 3-1 on the road.

The Chargers' schedule is full of one-score games that could have gone either way, and this might be another one.

Giants at Cowboys Week 10 Odds

• Spread: Cowboys (-17.5)
• New York Giants Moneyline: +1100
• Dallas Cowboys Moneyline: -2200
• Total: 39.5

The Giants again lost quarterback Daniel Jones to injury in Week 9, and Tommy DeVito replaced him. Jones suffered a torn ACL. They're already last in yards per play (4.1), so it's no wonder that their offensive expectations are below 12 points as of Monday based on the spread and total.

The Cowboys couldn't quite get ahead of the Eagles on Sunday in Week 9 despite multiple chances to do it. They're now 5-3. Despite the same record as the Steelers (-30 point differential), the Cowboys have a +72 point differential.

Commanders at Seahawks Week 10 Odds

• Spread: Seahawks (-5.5)
• Washington Commanders Moneyline: +220
• Seattle Seahawks Moneyline: -270
• Total: 44.5

Washington picked up a 20-17 win over the Patriots in Week 9 to move to 4-5 on the season and earn a respectable 3-2 road record.

Seattle is 3-1 at home and 4-1 inside the NFC, giving us some interesting trends for this matchup.

As expected, the Seahawks are favored fairly heavily in this matchup.

Jets at Raiders Week 10 Odds

• Spread: Jets (-1)
• New York Jets Moneyline: -108
• Las Vegas Raiders Moneyline: -108
• Total: 36.5

In a bit of a letdown primetime game, the total is under 40 points, and the Jets and Raiders are both starting quarterbacks they probably didn't anticipate before the season began.

For the Jets, they're also on a short week after playing on Monday Night Football in Week 9.

The Raiders earned a 30-6 win over the Giants in Week 9 with Aidan O'Connell starting. The team leaned on Josh Jacobs, who ran 26 times for 98 yards and 2 touchdowns.

Broncos at Bills Week 10 Odds

• Spread: Bills (-7)
• Denver Broncos Moneyline: +280
• Buffalo Bills Moneyline: -350
• Total: 47

There's a big spread in Buffalo's favor in Week 10 on Monday Night Football. This is Buffalo's third straight primetime matchup.

They've fallen to a 5-4 record and are just 2-4 in the AFC -- but are 4-1 at home.

The Broncos (3-5 overall) are on a two-game win streak and are coming off of a bye.

Denver is 1-4 in the AFC, and quarterback Russell Wilson has averaged 149.8 passing yards per game over his past four matchups. That probably won't cut it unless the Broncos' defense can stifle Josh Allen and the Bills.

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