Wake Forest vs Duke Prediction, Odds, Picks, Best Bets for Week 14 2025

The college football slate on Saturday includes the Duke Blue Devils taking on the Wake Forest Demon Deacons.

We've got you covered, in terms of the most important info about NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

Duke vs Wake Forest Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Duke: (-120) | Wake Forest: (+102)
• Spread: Duke: -2.5 (-106) | Wake Forest: +2.5 (-114)
• Total: 53.5 -- Over: (-110) | Under: (-110)

Duke vs Wake Forest Betting Trends

• Against the spread, Duke is 5-6-0 this season.
• Duke owns an ATS record of 4-4 as 2.5-point or greater favorites.
• There have been eight Duke games (of 11) that hit the over this year.
• Wake Forest is 8-3-0 against the spread this season.
• Wake Forest's ATS record as 2.5-point underdogs or more is 4-2.
• Of 11 Wake Forest games so far this season, six have hit the over.

Duke vs Wake Forest Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Demon Deacons win (53.9%)

Duke vs Wake Forest Point Spread

Wake Forest is the underdog by 2.5 points against Duke. Wake Forest is -106 to cover the spread, and Duke is -114.

Duke vs Wake Forest Over/Under

The over/under for the Duke versus Wake Forest game on Nov. 29 has been set at 53.5, with -110 odds on the over and -110 odds on the under.

Duke vs Wake Forest Moneyline

Looking at the moneyline for Wake Forest-Duke, Wake Forest is the underdog at +102, and Duke is -120.

Duke vs. Wake Forest Points Insights

Duke vs. Wake Forest Game Info

• Game day: Saturday, November 29, 2025
• Game time: 3:30 p.m. ET
• TV channel: ACC Network
• Location: Wilmington, North Carolina
• Stadium: Brooks Field at Wallace Wade Stadium

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Check out even more in-depth Duke vs. Wake Forest analysis on FanDuel Research.