Villanova vs USC Basketball Prediction, Odds, Picks, Best Bets for April 3

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The USC Trojans (17-17) go up against the Villanova Wildcats (20-14) at MGM Grand Garden Arena on April 3, 2025.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Villanova vs. USC Game Info and Odds

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Villanova win (68.7%)

Here's a look at some betting trends for Villanova (-5.5) versus USC on Thursday. The total is set at 150.5 points for this game.

Villanova has put together an 18-16-0 ATS record so far this year.
USC has put together a 15-19-0 ATS record so far this year.
As a 5.5-point favorite or more in 2024-25, Villanova is 9-7 against the spread compared to the 3-8 ATS record USC puts up as a 5.5-point underdog.
The Wildcats have covered the spread in a higher percentage of their home games than away games. They have covered 11 times in 17 opportunities when playing at home, and they've covered three times in 11 opportunities on the road.
The Trojans have performed better against the spread at home (8-11-0) than on the road (4-6-0) this season.

Villanova has won in 16, or 69.6%, of the 23 contests it has been named as the moneyline favorite in this year.
This season, the Wildcats have come away with a win 13 times in 15 chances when named as a favorite of at least -245 or shorter on the moneyline.
USC has won four of the 18 games it was the moneyline underdog this season (22.2%).
The Trojans have a 2-7 record (winning just 22.2% of their games) when playing as a moneyline underdog of +198 or longer.
Bookmakers have implied with the moneyline set for this matchup that Villanova has a 71% chance of pulling out a win.

Villanova has a +215 scoring differential, topping opponents by 6.3 points per game. It is putting up 73.7 points per game to rank 182nd in college basketball and is allowing 67.4 per contest to rank 50th in college basketball.
Eric Dixon's team-leading 23.0 points per game ranks first in college basketball.
USC is outscoring opponents by 2.2 points per game, with a +75 scoring differential overall. It puts up 77.2 points per game (86th in college basketball) and allows 75.0 per outing (270th in college basketball).
Desmond Claude's team-leading 16.0 points per game rank him 188th in the country.
The Wildcats prevail in the rebound battle by an average of 3.0 boards. They are collecting 30.4 rebounds per game (279th in college basketball) compared to their opponents' 27.4 per outing.
Wooga Poplar paces the team with 6.9 rebounds per game (177th in college basketball play).
The Trojans average 29.1 rebounds per game (326th in college basketball), compared to the 28.9 of their opponents.
Saint Thomas' 5.7 rebounds per game lead the Trojans and rank 395th in the nation.
Villanova records 103.6 points per 100 possessions (27th in college basketball), while allowing 94.7 points per 100 possessions (214th in college basketball).
The Trojans' 100.3 points per 100 possessions on offense rank 71st in college basketball, and the 97.4 points they concede per 100 possessions rank 291st in college basketball.

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