Vanderbilt vs Iowa Prediction, Odds, Picks, Best Bets for ReliaQuest Bowl 2025

NCAA football action on Wednesday includes the Vanderbilt Commodores playing the Iowa Hawkeyes.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the vital information about today's NCAA football betting odds.

Vanderbilt vs Iowa Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Vanderbilt: (-225) | Iowa: (+184)
• Spread: Vanderbilt: -6.5 (-110) | Iowa: +6.5 (-110)
• Total: 46.5 -- Over: (-118) | Under: (-104)

Vanderbilt vs Iowa Betting Trends

• Vanderbilt has beaten the spread 10 times in 12 games.
• As 6.5-point favorites or more, Vanderbilt is 4-1 against the spread.
• This year, eight of Vanderbilt's 12 games have gone over the point total.
• Iowa's record against the spread in 2025 is 9-3-0.
• Iowa is unbeaten ATS (2-0) as a 6.5-point underdog or greater this season.
• There have been five Iowa games (out of 12) that hit the over this season.

Vanderbilt vs Iowa Point Spread

Vanderbilt is favored by 6.5 points (-110 to cover) in this matchup. Iowa, the underdog, is -110.

Vanderbilt vs Iowa Over/Under

The Vanderbilt-Iowa matchup on Dec. 31 has been given an over/under of 46.5 points. The over is -118 and the under is -104.

Vanderbilt vs Iowa Moneyline

Iowa is the underdog, +184 on the moneyline, while Vanderbilt is a -225 favorite.

Vanderbilt vs. Iowa Points Insights

Vanderbilt vs. Iowa Game Info

• Game day: Wednesday, December 31, 2025
• Game time: 12 p.m. ET
• TV channel: ESPN
• Location: Tampa, Florida
• Stadium: Raymond James Stadium

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Check out even more in-depth Vanderbilt vs. Iowa analysis on FanDuel Research.