UTSA vs South Florida Prediction, Odds, Picks, Best Bets for Week 6 2026

The UTSA Roadrunners versus the South Florida Bulls is on the college football schedule for Thursday.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

UTSA vs South Florida Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: UTSA: (-310) | South Florida: (+245)
• Spread: UTSA: -6.5 (-134) | South Florida: +6.5 (110)
• Total: 50.5 -- Over: (-110) | Under: (-110)

UTSA vs South Florida Betting Trends

• UTSA has three wins in five games against the spread this season.
• As a 6.5-point or greater favorite, UTSA has one win ATS (1-2) this season.
• UTSA has had two games (out of five) go over the total this season.
• South Florida has won twice against the spread this season.
• A pair of South Florida five games in 2026 have hit the over.

UTSA vs South Florida Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Roadrunners win (55.8%)

UTSA vs South Florida Point Spread

South Florida is the underdog by 6.5 points against UTSA. South Florida is -134 to cover the spread, and UTSA is +110.

UTSA vs South Florida Over/Under

A combined point total of 50.5 has been set for UTSA-South Florida on Oct. 8, with the over at -110 and the under at -110.

UTSA vs South Florida Moneyline

UTSA is the favorite, -310 on the moneyline, while South Florida is a +245 underdog.

UTSA vs. South Florida Points Insights

UTSA vs. South Florida Game Info

• Game day: Thursday, October 8, 2026
• Game time: 7:30 p.m. ET
• TV channel: ESPN
• Location: San Antonio, Texas
• Stadium: Alamodome

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Check out even more in-depth UTSA vs. South Florida analysis on FanDuel Research.