USC vs Iowa Prediction, Odds, Picks, Best Bets for Week 12 2025

In college football action on Saturday, the USC Trojans play the Iowa Hawkeyes.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

USC vs Iowa Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: USC: (-240) | Iowa: (+198)
• Spread: USC: -6.5 (-115) | Iowa: +6.5 (-105)
• Total: 48.5 -- Over: (-110) | Under: (-110)

USC vs Iowa Betting Trends

• USC has five wins in nine games against the spread this year.
• For the season, USC is 3-3 as 6.5-point or better favorites.
• There have been five USC games (of nine) that hit the over this season.
• Iowa is 7-2-0 against the spread this season.
• Iowa has covered every time (1-0) as a 6.5-point or greater underdog this year.
• Of nine Iowa games so far this year, four have hit the over.

USC vs Iowa Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Trojans win (67.6%)

USC vs Iowa Point Spread

Iowa is an underdog by 6.5 points against USC. Iowa is -105 to cover the spread, and USC is -115.

USC vs Iowa Over/Under

A total of 48.5 points has been set for the USC-Iowa game on Nov. 15, with the over available at -110 and the under at -110.

USC vs Iowa Moneyline

Iowa is a +198 underdog on the moneyline, while USC is a -240 favorite.

USC vs. Iowa Points Insights

USC vs. Iowa Game Info

• Game day: Saturday, November 15, 2025
• Game time: 3:30 p.m. ET
• TV channel: BTN
• Location: Los Angeles, California
• Stadium: Los Angeles Memorial Coliseum

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Check out even more in-depth USC vs. Iowa analysis on FanDuel Research.