Twins vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for March 27

Odds updated as of 3:17 p.m.

The Minnesota Twins are among the MLB squads playing on Thursday, up against the St. Louis Cardinals.

All the info you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Twins vs Cardinals Game Info

• Minnesota Twins (0-0) vs. St. Louis Cardinals (0-0)
• Date: Thursday, March 27, 2025
• Time: 4:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: FDSMW and MNNT

Twins vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIN: (-112) | STL: (-104)
• Spread: MIN: -1.5 (+152) | STL: +1.5 (-184)
• Total: 7.5 -- Over: (-102) | Under: (-120)

Twins vs Cardinals Probable Starting Pitchers

Probable Pitchers: Pablo Lopez (Twins) - 0-0, 0.00 ERA vs Sonny Gray (Cardinals) - 0-0, 0.00 ERA

The Twins will give the nod to Pablo Lopez versus the Cardinals and Sonny Gray. In games Lopez pitched with a spread last season, his team was 14-18-0 ATS. Lopez and his team had a 17-9 record when he pitched as a favorite last season. Last season Gray and his team had a 12-16-0 record against the spread in games he pitched. Gray and his team finished with a 2-3 record in the five games he pitched when they were moneyline underdogs a season ago.

Twins vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (54.9%)

Twins vs Cardinals Moneyline

• Looking at the moneyline for Twins-Cardinals, Minnesota is the favorite at -112, and St. Louis is -104 playing at home.

Twins vs Cardinals Spread

• The Cardinals are hosting the Twins, and are +1.5 on the runline. The Cardinals are +152 to cover the spread, and the Twins are -184.

Twins vs Cardinals Over/Under

• A total of 7.5 runs has been set for the Twins-Cardinals game on March 27, with the over available at -102 and the under at -120.

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Twins vs Cardinals Betting Trends

• The Twins won in 62, or 56.9%, of the 109 contests they were named as odds-on favorites in the last year.
• Last season Minnesota came away with a win 61 times in 107 chances when named as a favorite of at least -112 or shorter on the moneyline.
• The Twins and their opponents hit the over in 80 of their 158 games with a total last season.
• The Cardinals put together a 40-42 record in games last season when they were listed as the moneyline underdog (winning 48.8% of those games).
• When playing as a moneyline underdog with odds of -104 or longer last year, St. Louis went 39-36 (52%).
• The Cardinals played in 157 games with a set over/under last season, and combined with their opponents to go over the total 72 times (72-83-2).

Twins Player Leaders

• Willi Castro had 138 base hits and an OBP of .331 to go with a slugging percentage of .385 last season.
• Carlos Correa slashed .310/.388/.517 and finished with an OPS of .905.
• Ryan Jeffers ended his last campaign with 93 hits, an OBP of .300, plus a slugging percentage of .432.
• Byron Buxton slashed .279/.335/.524 and finished with an OPS of .859.

Cardinals Player Leaders

• Brendan Donovan racked up an on-base percentage of .342 and a slugging percentage of .417 a season ago.
• Alec Burleson racked up 147 hits with a .269 batting average.
• Masyn Winn had 32 doubles, five triples, 15 home runs and 41 walks while batting .267 last season.
• Nolan Arenado hit .272 with 23 doubles, 16 home runs and 44 walks.

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