Twins vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for April 6

Odds updated as of 1:13 p.m.

The Minnesota Twins are among the MLB squads playing on Sunday, up against the Houston Astros.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info regarding this game.

Twins vs Astros Game Info

• Minnesota Twins (3-5) vs. Houston Astros (3-5)
• Date: Sunday, April 6, 2025
• Time: 2:10 p.m. ET
• Venue: Target Field -- Minneapolis, Minnesota
• Coverage: MNNT and SCHN

Twins vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIN: (-112) | HOU: (-104)
• Spread: MIN: +1.5 (-176) | HOU: -1.5 (+146)
• Total: 8.5 -- Over: (-110) | Under: (-110)

Twins vs Astros Probable Starting Pitchers

Probable Pitchers: Chris Paddack (Twins) - 0-1, 24.30 ERA vs Ronel Blanco (Astros) - 0-1, 5.40 ERA

This contest's pitching matchup is set, as the Twins will send Chris Paddack (0-1) to the mound, while Ronel Blanco (0-1) will answer the bell for the Astros. Paddack and his team failed to cover the spread in his only opportunity this season as a starter. Paddack's team lost his only start as a favorite this season. Blanco has started only one game with a set spread, which the Astros failed to cover. The Astros have always been the moneyline underdog when Blanco starts this season.

Twins vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (52%)

Twins vs Astros Moneyline

• Minnesota is the favorite, -112 on the moneyline, while Houston is a -104 underdog on the road.

Twins vs Astros Spread

• The Astros are 1.5-run favorites against the spread for this matchup with the Twins. The Astros are +146 to cover, while the Twins are -176 to cover as a 1.5-run underdog on the runline.

Twins vs Astros Over/Under

• The Twins-Astros contest on April 6 has been given an over/under of 8.5 runs. The over is set at -110 and the under at -110.

Bet on Minnesota Twins vs. Houston Astros on FanDuel today!

Twins vs Astros Betting Trends

• The Twins have been victorious in three of the eight contests they have been chosen as favorites in this season.
• This season Minnesota has been victorious three times in eight chances when named as a favorite of at least -112 on the moneyline.
• The Twins and their opponents have gone over the total this season in four of their eight opportunities.
• The Twins have an against the spread record of 3-5-0 in eight games with a line this season.
• The Astros have been the moneyline underdog three total times this season. They've finished 1-2 in those games.
• When it has played as a moneyline underdog with odds of -104 or longer, Houston has a record of 1-2 (33.3%).
• In the eight games oddsmakers have set an over/under for the Astros, they have combined with opponents to go over the total two times (2-5-1).
• The Astros have a 2-6-0 record against the spread this season.

Twins Player Leaders

• Harrison Bader is batting .211 with a double and three home runs. He has an on-base percentage of .211 and a slugging percentage of .737.
• Willi Castro has six hits and an OBP of .333 to go with a slugging percentage of .462. All three of those stats rank first among Minnesota hitters this season. He's batting .231.
• He ranks 110th in batting average, 81st in on-base percentage and 72nd in slugging among qualifying hitters.
• Byron Buxton has an OPS of .624, fueled by an OBP of .267 and a team-best slugging percentage of .357 this season.
• Matt Wallner is batting .160 with a .300 OBP and one RBI for Minnesota this season.
• Wallner has hit safely in two straight games. During his last five outings he is hitting .235 with three doubles, a triple, four walks and an RBI.

Astros Player Leaders

• Jeremy Pena is hitting .185 with two home runs and two walks. He's slugging .407 with an on-base percentage of .267.
• Including all qualifying hitters in the majors, his batting average puts him 146th, his on-base percentage ranks 144th, and he is 91st in slugging.
• Jose Altuve's 12 hits, .400 OBP and .545 slugging percentage are all team-highs. He has a batting average of .364.
• His batting average ranks 14th among all qualified players, his on-base percentage ranks 30th, and he is 44th in slugging.
• Brendan Rodgers is hitting .316 with two doubles and three walks.
• Isaac Paredes is hitting .148 with a double and five walks.

Twins vs Astros Head to Head

• 4/5/2025: 6-1 MIN (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/3/2025: 5-2 HOU (Favorite: Twins, Spread: -1.5, Total: 7, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 7/7/2024: 3-2 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 7/6/2024: 9-3 MIN (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 7/5/2024: 13-12 HOU (Favorite: Twins, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 6/2/2024: 4-3 MIN (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 6/1/2024: 5-2 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 5/31/2024: 6-1 MIN (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 10/11/2023: 3-2 HOU (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 10/10/2023: 9-1 HOU (Favorite: Twins, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +114)

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