Troy vs Southern Miss Prediction, Odds, Picks, Best Bets for Week 6 2026

On Tuesday in college football, the Troy Trojans are up against the Southern Miss Golden Eagles.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Troy vs Southern Miss Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Troy: (-420) | Southern Miss: (+330)
• Spread: Troy: -10.5 (-105) | Southern Miss: +10.5 (-115)
• Total: 49.5 -- Over: (-105) | Under: (-115)

Troy vs Southern Miss Betting Trends

• Troy hasn won once against the spread this season.
• Troy has yet to win ATS (0-2) when playing as at least 10.5-point favorites this season.
• Not one of Troy's four games has hit the over in 2026.
• Southern Miss has posted two wins against the spread this year.
• Southern Miss has one win ATS (1-1) as a 10.5-point underdog or greater this year.
• Two Southern Miss games (of four) have hit the over this year.

Troy vs Southern Miss Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Trojans win (78.1%)

Troy vs Southern Miss Point Spread

Southern Miss is listed as an underdog by 10.5 points (-115 odds), and Troy, the favorite, is -105 to cover.

Troy vs Southern Miss Over/Under

An over/under of 49.5 has been set for Troy-Southern Miss on Oct. 6, with the over being -105 and the under -115.

Troy vs Southern Miss Moneyline

Southern Miss is a +330 underdog on the moneyline, while Troy is a -420 favorite.

Troy vs. Southern Miss Points Insights

Troy vs. Southern Miss Game Info

• Game day: Tuesday, October 6, 2026
• Game time: 8 p.m. ET
• TV channel: ESPN2
• Location: Troy, Alabama
• Stadium: Veterans Memorial Stadium (AL)

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Check out even more in-depth Troy vs. Southern Miss analysis on FanDuel Research.