Tigers vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for May 23

Odds updated as of 7:13 a.m.

The Detroit Tigers versus the Cleveland Guardians is on the MLB schedule for Friday.

All the information you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Tigers vs Guardians Game Info

• Detroit Tigers (33-18) vs. Cleveland Guardians (27-22)
• Date: Friday, May 23, 2025
• Time: 7:10 p.m. ET
• Venue: Comerica Park -- Detroit, Michigan
• Coverage: FDSDET and CLEG

Tigers vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: DET: (-134) | CLE: (+114)
• Spread: DET: -1.5 (+140) | CLE: +1.5 (-170)
• Total: 8.5 -- Over: (-110) | Under: (-110)

Tigers vs Guardians Probable Starting Pitchers

Probable Pitchers: Jackson Jobe (Tigers) - 4-0, 4.12 ERA vs Slade Cecconi (Guardians) - 0-1, 5.40 ERA

The probable starters are Jackson Jobe (4-0) for the Tigers and Slade Cecconi (0-1) for the Guardians. When Jobe starts, his team is 7-1-0 against the spread this season. Jobe's team is 2-0 this season when he starts and they're favored on the moneyline. Cecconi has started only one game with a set spread, which the Guardians failed to cover. The Guardians have always been the moneyline underdog when Cecconi starts this season.

Tigers vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Tigers win (60.2%)

Tigers vs Guardians Moneyline

• Cleveland is a +114 underdog on the moneyline, while Detroit is a -134 favorite at home.

Tigers vs Guardians Spread

• The Tigers are hosting the Guardians and are favored by 1.5 runs (+140 to cover) on the runline. Cleveland is -170 to cover.

Tigers vs Guardians Over/Under

• The over/under for Tigers-Guardians on May 23 is 8.5. The over is -110, and the under is -110.

Bet on Detroit Tigers vs. Cleveland Guardians on FanDuel today!

Tigers vs Guardians Betting Trends

• The Tigers have been victorious in 21, or 72.4%, of the 29 contests they have been chosen as favorites in this season.
• This season Detroit has been victorious 18 times in 22 chances when named as a favorite of at least -134 on the moneyline.
• Contests with the Tigers have gone over the total set by oddsmakers in 25 of 50 chances this season.
• The Tigers have an against the spread mark of 27-23-0 in 50 games with a line this season.
• The Guardians have gone 14-14 in games they were listed as the moneyline underdog (winning 50% of those games).
• Cleveland is 4-7 (winning just 36.4% of its games) when it has played as a moneyline underdog of +114 or longer.
• The Guardians have played in 47 games with a set over/under, and have combined with opponents to go over the total 22 times (22-23-2).
• The Guardians have gone 22-25-0 against the spread this season.

Tigers Player Leaders

• Spencer Torkelson leads Detroit with 43 hits, batting .244 this season with 25 extra-base hits. He has an on-base percentage of .355 and a slugging percentage of .523.
• Among qualifying hitters, he is 98th in batting average, his on-base percentage ranks 54th, and he is 18th in slugging.
• Riley Greene leads Detroit in slugging percentage (.521) thanks to 22 extra-base hits. He's batting .281 with an on-base percentage of .337.
• He is 39th in batting average, 70th in on-base percentage and 20th in slugging among qualifying batters.
• Gleyber Torres leads Detroit with an OBP of .358 this season while batting .277 with 16 walks and 20 runs scored.
• Kerry Carpenter has been key for Detroit with 48 hits, an OBP of .309 plus a slugging percentage of .500.

Guardians Player Leaders

• Jose Ramirez has 54 hits, a team-best for the Guardians. He's batting .307 and slugging .517 with an on-base percentage of .364.
• Including all the qualified hitters in the big leagues, he ranks 11th in batting average, 39th in on-base percentage and 22nd in slugging percentage.
• Ramirez hopes to build on a 15-game hitting streak in this matchup. In his last 10 outings he is hitting .375 with two doubles, three home runs, three walks and six RBIs.
• Steven Kwan's .373 OBP and .433 slugging percentage are both team-highs. He has a batting average of .314.
• Including all qualifying hitters, he ranks eighth in batting average, 28th in on-base percentage and 67th in slugging percentage.
• Carlos Santana is batting .235 with four doubles, six home runs and 26 walks.
• Kyle Manzardo is hitting .212 with five doubles, two triples, 10 home runs and 20 walks.

Tigers vs Guardians Head to Head

• 5/22/2025: 7-0 CLE (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 10/12/2024: 7-3 CLE (Favorite: Tigers, Spread: -1.5, Total: 6, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 10/10/2024: 5-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 10/9/2024: 3-0 DET (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 10/7/2024: 3-0 DET (Favorite: Tigers, Spread: -1.5, Total: 6, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 10/5/2024: 7-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 7/30/2024: 5-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 7/29/2024: 8-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 7/25/2024: 3-0 DET (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 7/24/2024: 2-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -144, Underdog Moneyline: +122)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!