Thunder vs. Nuggets Prediction, Odds, Picks, Best Bets for Oct. 22

Thunder vs. Nuggets Game Info

• Date: Thursday, October 22, 2026
• Time: 9:30 p.m. ET
• Venue: Paycom Center -- Oklahoma City, Oklahoma
• Coverage: ESPN

The Oklahoma City Thunder (1-0) host the Denver Nuggets (0-0) in a matchup of Northwest Division teams at Paycom Center, tipping off at 9:30 p.m. ET on Thursday, October 22, 2026. The Nuggets are 8.5-point underdogs in the game, the first matchup between the teams this season. The matchup has an over/under set at 236.5 points.

Thunder vs. Nuggets Odds & Spread

All NBA betting lines, odds and prop bets are from FanDuel Sportsbook.

Thunder vs. Nuggets Prediction & Pick

All NBA win probability predictions and picks are according to numberFire.
Prediction: Thunder win (70.6%)

Thunder vs. Nuggets Betting Trends

• The Thunder went 39-42-1 ATS last season.
• The Nuggets went 4-0 as underdogs of 8.5 points or greater last year.
• Thunder games hit the over 45 out of 82 times last season.
• Out of 82 Nuggets games last season, 52 hit the over.
• Oklahoma City did a better job covering the spread when playing on the road (20-19-1) than it did at home (19-23-0) last year.
• Last year, Denver was 20-21-0 at home against the spread (.488 winning percentage). Away, it was 24-17-0 ATS (.585).

Thunder Leaders

• Shai Gilgeous-Alexander posted 31.1 points, 4.3 rebounds and 6.6 assists last year. He also drained 55.3% of his shots from the field and 38.6% from 3-point range, with 1.7 triples per contest.
• Last season, Chet Holmgren recorded an average of 17.1 points, 8.9 rebounds and 1.7 assists per game.
• Cason Wallace averaged 8.6 points, 3.1 rebounds and 2.6 assists. He drained 43.2% of his shots from the floor and 35.1% from 3-point range, with 1.3 triples per contest.
• Ajay Mitchell recorded 13.6 points, 3.3 rebounds and 3.6 assists. He made 48.5% of his shots from the field and 34.7% from 3-point range, with 1.1 treys per contest.
• Isaiah Hartenstein posted 9.2 points, 9.4 boards and 3.5 assists per contest, plus 1 steal and 0.8 blocks.

Nuggets Leaders

• Nikola Jokic averaged 27.7 points, 12.9 rebounds and 10.7 assists last season. At the other end, he put up 1.4 steals and 0.8 blocked shots.
• Jamal Murray collected 25.4 points, 4.4 boards and 7.1 assists last year, shooting 48.3% from the field and 43.5% from downtown (seventh in league), with 3.3 made 3-pointers per game (fifth in league).
• DeMar DeRozan collected 18.4 points, 2.9 boards and 4.1 assists, shooting 49.7% from the floor.
• Marvin Bagley III recorded 10.5 points, 1.4 assists and 6.1 boards.
• Cameron Johnson averaged 12.2 points, 2.4 assists and 3.8 rebounds.

For more NBA betting insights, check out FanDuel Research's NBA home page.

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