Tennessee vs Louisville College Basketball Prediction, Odds, Picks, Best Bets for Dec. 16

The Tennessee Volunteers (7-3) will try to end a three-game losing streak when they host the Louisville Cardinals (9-1) on December 16, 2025 at Thompson-Boling Arena. The contest airs on ESPN.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Tennessee vs. Louisville Game Info and Odds

• Game day: Tuesday, December 16, 2025
• Game time: 7 p.m. ET
• TV channel: ESPN
• Location: Knoxville, Tennessee
• Arena: Thompson-Boling Arena

Tennessee vs. Louisville Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Tennessee win (64.5%)

If you plan to place a wager on Tennessee-Louisville contest (in which Tennessee is a 1.5-point favorite and the over/under has been set at 157.5 points), keep reading for some betting trends and insights for Tuesday's game.

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Tennessee vs. Louisville: ATS Betting Stats and Trends

• Tennessee has covered three times in 10 matchups with a spread this season.
• Louisville has put together a 7-3-0 record against the spread this year.
• The Volunteers sported a better record against the spread when playing at home (9-8-0) than they did in away games (5-6-0) last season.
• In 2024-25 against the spread, the Cardinals had a lower winning percentage at home (.471, 8-9-0 record) than on the road (.818, 9-2-0).

Tennessee vs. Louisville: Moneyline Betting Stats

• Tennessee has come away with four wins in the seven contests it has been listed as the moneyline favorite in this season.
• This year, the Volunteers have won four of seven games when listed as at least -125 or better on the moneyline.
• Louisville is playing as the moneyline underdog in its first game this season.
• The Cardinals have not yet played a game with moneyline odds of +104 or longer.
• Tennessee has an implied victory probability of 55.6% according to the moneyline set by oddsmakers for this matchup.

Tennessee vs. Louisville Head-to-Head Comparison

• Last year, Tennessee was 167th in the country on offense (74 points scored per game) and 10th-best defensively (63.1 points allowed).
• Last season, Tennessee was 105th in the nation in rebounds (33.2 per game) and 13th-best in rebounds conceded (27.5).
• At 15.4 assists per game last season, Tennessee was 61st in the nation.
• Last year, Tennessee was 40th in college basketball in turnovers committed (9.6 per game) and 250th in turnovers forced (10.5).
• Louisville ranked 65th in college basketball last season with 78.5 points per game. At the other end of the court, it ranked 89th with 69.5 points allowed per game.
• With 34.6 rebounds per game, Louisville ranked 47th in the country. It allowed 30.2 rebounds per contest, which ranked 114th in college basketball.
• Louisville ranked 148th in the country with 13.9 assists per game.
• Last season Louisville averaged 10.9 turnovers per game (150th-ranked in college basketball) and forced 12.2 turnovers per contest (93rd-ranked).

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