Steelers vs Colts Prediction, Odds, Picks, Best Bets for NFL Week 5

The NFL's Sunday slate includes the Pittsburgh Steelers taking on the Indianapolis Colts.

Get the latest NFL odds ahead of this matchup on FanDuel Sportsbook.

Steelers vs Colts Prediction & Pick

All NFL win probability predictions and picks are according to numberFire.
Prediction: Colts win (56.4%)

Steelers vs Colts Point Spread

The Steelers are 2.5-point favorites against the Colts. The Steelers are -115 to cover the spread, while the Colts are -105 to cover as a 2.5-point underdog.

Steelers vs Colts Over/Under

The over/under for the Steelers versus Colts matchup on Oct. 11 has been set at 43.5, with -110 odds on the over and -110 odds on the under.

Steelers vs Colts Moneyline

Pittsburgh is a -148 favorite on the moneyline, while Indianapolis is a +126 underdog on the road.

Steelers vs Colts Betting Trends

• Pittsburgh has won twice against the spread this year.
• As a 2.5-point favorite or greater, the Steelers have one win ATS (1-1) this season.
• Two Steelers games (out of four) have gone over the point total this year.
• The Colts' record against the spread is 3-1-0.
• As a 2.5-point underdog or more, Indianapolis has one win ATS (1-1) this season.
• Two of the Colts' four games in 2026 have hit the over.

Check out even more in-depth Steelers vs. Colts analysis on FanDuel Research.

Steelers vs Colts Odds & Spread

• All NFL odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PIT: (-148) | IND: (+126)
• Spread: PIT: -2.5 (-115) | IND: +2.5 (-105)
• Total: 43.5 -- Over: (-110) | Under: (-110)

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