Spurs vs. Trail Blazers NBA Playoffs Prediction, Odds, Picks, Best Bets for April 21

Spurs vs. Trail Blazers Game Info

• Date: Tuesday, April 21, 2026
• Time: 8 p.m. ET
• Venue: Frost Bank Center -- San Antonio, Texas
• Coverage: NBC/Peacock

The San Antonio Spurs are massive 11.5-point favorites for Game 2 of the opening round of the NBA Playoffs against the Portland Trail Blazers at Frost Bank Center on Tuesday, beginning at 8 p.m. ET on NBC/Peacock. The Spurs hold a 1-0 series lead. The point total in the matchup is 220.5.

Spurs vs. Trail Blazers Odds & Spread

All NBA betting lines, odds and prop bets are from FanDuel Sportsbook.

Spurs vs. Trail Blazers Prediction & Pick

All NBA win probability predictions and picks are according to numberFire.
Prediction: Spurs win (76.3%)

Spurs vs. Trail Blazers Betting Trends

• The Spurs have put together a 43-34-4 record against the spread this season.
• In the Trail Blazers' 82 games this season, they have 45 wins against the spread.
• Games involving the Spurs have hit the over 36 times this season.
• Trail Blazers games this year have eclipsed the over/under 51.2% of the time (42 out of 82 games with a set point total).
• When playing at home, San Antonio has a worse record against the spread (19-17-3) compared to its ATS record on the road (24-17-1).
• In home games, the Spurs eclipse the over/under 45% of the time (18 of 40 games). They've hit the over in 42.9% of road games (18 of 42 contests).
• Against the spread, Portland has been better at home (25-16-0) than away (20-21-0).
• In 2025-26, a higher percentage of the Trail Blazers' games have finished above the over/under at home (61%, 25 of 41) than on the road (41.5%, 17 of 41).

Spurs Leaders

• Victor Wembanyama averages 25 points, 11.5 boards and 3.1 assists, shooting 51.2% from the floor and 34.9% from beyond the arc, with 1.9 made 3-pointers per contest.
• De'Aaron Fox is averaging 18.6 points, 6.2 assists and 3.8 boards.
• Stephon Castle is averaging 16.6 points, 7.4 assists and 5.3 boards.
• Keldon Johnson is averaging 13.2 points, 5.4 boards and 1.4 assists. Defensively, he averages 0.6 steals and 0.1 blocked shots.
• Julian Champagnie averages 11.1 points, 5.8 rebounds and 1.5 assists, shooting 43.7% from the field and 38.1% from beyond the arc, with 2.4 made 3-pointers per contest.

Trail Blazers Leaders

• Deni Avdija averages 24.2 points for the Trail Blazers, plus 6.9 boards and 6.7 assists.
• Per game, Donovan Clingan gets the Trail Blazers 12.1 points, 11.6 boards and 2.1 assists. He also averages 0.6 steals and 1.7 blocks (fourth in league).
• The Trail Blazers receive 13.4 points per game from Toumani Camara, plus 5.1 rebounds and 2.5 assists.
• Jrue Holiday's numbers on the season are 16.3 points, 4.6 boards and 6.1 assists per game. He is draining 45.1% of his shots from the field and 37.8% from beyond the arc, with an average of 2.6 treys.
• Jerami Grant averages 18.6 points, 3.5 rebounds and 2.1 assists. He is sinking 45.3% of his shots from the floor and 38.9% from 3-point range, with 2.4 treys per contest.

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