Celtics vs. 76ers NBA Playoffs Prediction, Odds, Picks, Best Bets for April 21

Celtics vs. 76ers Game Info

• Date: Tuesday, April 21, 2026
• Time: 7 p.m. ET
• Venue: TD Garden -- Boston, Massachusetts
• Coverage: Peacock and NBC Sports

The Boston Celtics are double-digit 13.5-point favorites for Game 2 of the opening round of the NBA Playoffs against the Philadelphia 76ers at TD Garden on Tuesday, beginning at 7 p.m. ET on Peacock and NBC Sports. The Celtics have a 1-0 lead in the series. The point total for the matchup is 216.5.

Celtics vs. 76ers Odds & Spread

All NBA betting lines, odds and prop bets are from FanDuel Sportsbook.

Celtics vs. 76ers Prediction & Pick

All NBA win probability predictions and picks are according to numberFire.
Prediction: Celtics win (77.7%)

Celtics vs. 76ers Betting Trends

• The Celtics are 49-32-1 against the spread this season.
• In the 76ers' 82 games this year, they have 40 wins against the spread.
• Celtics games have finished with a final combined score above the over/under 30 times this season.
• 76ers games this year have gone over the total in 41 of 82 opportunities (50%).
• At home, Boston has a worse record against the spread (23-18-0) compared to its ATS record in away games (26-14-1).
• When playing at home, the Celtics go over the over/under 36.6% of the time (15 of 41 games). They hit the over in the same percentage of road games (15 of 41 contests).
• Philadelphia has been better against the spread on the road (22-18-1) than at home (18-22-1) this season.
• Looking at the over/under, 76ers games have gone over 20 of 41 times at home (48.8%), and 21 of 41 on the road (51.2%).

Celtics Leaders

• Jaylen Brown averages 28.7 points, 6.9 rebounds and 5.1 assists, shooting 47.7% from the floor and 34.7% from downtown, with 2 made treys per contest.
• Derrick White's numbers on the season are 16.5 points, 4.4 boards and 5.4 assists per game, shooting 39.4% from the floor and 32.7% from beyond the arc, with an average of 2.7 made 3-pointers.
• Payton Pritchard averages 17 points, 3.9 rebounds and 5.2 assists, shooting 46.4% from the field and 37.7% from beyond the arc, with 2.7 made treys per game.
• Nikola Vucevic's numbers on the season are 15.1 points, 8.4 rebounds and 3.3 assists per contest, shooting 49.3% from the field and 36.9% from beyond the arc, with an average of 1.6 made 3-pointers.
• Neemias Queta is averaging 10.2 points, 8.4 boards and 1.7 assists.

76ers Leaders

• Tyrese Maxey's numbers on the season are 28.3 points, 4.1 rebounds and 6.6 assists per game. He is also sinking 46.2% of his shots from the field and 36.7% from beyond the arc, with an average of 3.1 triples (ninth in league).
• VJ Edgecombe's numbers on the season are 16 points, 5.6 rebounds and 4.2 assists per game. He is sinking 43.8% of his shots from the field and 35.4% from 3-point range, with an average of 2 triples.
• Per game, Quentin Grimes provides the 76ers 13.4 points, 3.6 rebounds and 3.3 assists, plus 0.9 steals and 0.4 blocks.
• The 76ers are getting 26.9 points, 7.7 rebounds and 3.9 assists per game from Joel Embiid.
• The 76ers are receiving 6.4 points, 8.4 boards and 1.3 assists per game from Andre Drummond.

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