Reds vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for May 18

Odds updated as of 1:11 a.m.

The Sunday schedule in MLB includes a matchup between the Cincinnati Reds and the Cleveland Guardians.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Reds vs Guardians Game Info

• Cincinnati Reds (23-24) vs. Cleveland Guardians (25-20)
• Date: Sunday, May 18, 2025
• Time: 1:40 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: MLB Network, FDSOH, and CLEG

Reds vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CIN: (-126) | CLE: (+108)
• Spread: CIN: -1.5 (+164) | CLE: +1.5 (-200)
• Total: 9 -- Over: (-110) | Under: (-110)

Reds vs Guardians Probable Starting Pitchers

Probable Pitchers: Andrew Abbott (Reds) - 2-0, 2.10 ERA vs Luis Ortiz (Guardians) - 2-4, 4.78 ERA

The Reds will call on Andrew Abbott (2-0) against the Guardians and Luis Ortiz (2-4). Abbott and his team are 4-1-0 ATS this season when he starts. Abbott's team is 2-0 this season when he starts and they're favored on the moneyline. The Guardians are 3-5-0 against the spread when Ortiz starts. The Guardians are 1-3 in Ortiz's four starts this season that they were the underdog on the moneyline.

Reds vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Reds win (55.6%)

Reds vs Guardians Moneyline

• Cincinnati is a -126 favorite on the moneyline, while Cleveland is a +108 underdog on the road.

Reds vs Guardians Spread

• The Guardians are at +1.5 on the runline against the Reds. The Guardians are -200 to cover the spread, and the Reds are +164.

Reds vs Guardians Over/Under

• Reds versus Guardians on May 18 has an over/under of 9 runs, with the odds on the over -110 and the under set at -110.

Bet on Cincinnati Reds vs. Cleveland Guardians on FanDuel today!

Reds vs Guardians Betting Trends

• The Reds have come away with 10 wins in the 18 contests they have been listed as the favorites in this season.
• Cincinnati has a record of 6-5 in contests when oddsmakers favor them by -126 or more on the moneyline.
• The Reds and their opponents have gone over in 18 of their 45 games with a total set by sportsbooks this season.
• The Reds have posted a record of 24-21-0 against the spread this season.
• The Guardians have won 48% of the games this season they were the underdog on the moneyline (12-13).
• Cleveland has gone 4-9 when playing as a moneyline underdog with odds of +108 or longer (30.8%).
• The Guardians have played in 44 games with a set over/under, and have combined with opponents to go over the total 22 times (22-20-2).
• The Guardians have put together a 20-24-0 record ATS this season.

Reds Player Leaders

• Elly De La Cruz leads Cincinnati with 46 hits and a team-best slugging percentage of .415. He's batting .251 with an on-base percentage of .324.
• Among all qualifying batters in the majors, he is 91st in batting average, 90th in on-base percentage, and 86th in slugging.
• TJ Friedl is batting .268 with seven doubles, a triple, three home runs and 21 walks. He's slugging .378 with an on-base percentage of .354.
• His batting average is 58th among qualified players, his on-base percentage 52nd, and his slugging percentage 111th.
• Gavin Lux leads Cincinnati in OBP (.386) this season, fueled by 43 hits.
• Lux has logged a hit or more in three games in a row. During his last five outings he is hitting .353 with two doubles, a walk and an RBI.
• Austin Hays is batting .316 with a .368 OBP and 17 RBI for Cincinnati this season.
• Hays takes a four-game hitting streak into this game. During his last five outings he is batting .278 with two doubles, a home run, a walk and four RBIs.

Guardians Player Leaders

• Jose Ramirez leads the Guardians with 46 hits. He's batting .293 and slugging .516 with an on-base percentage of .358.
• Including all qualifying hitters in the majors, he is 30th in batting average, 45th in on-base percentage and 24th in slugging percentage.
• Ramirez hopes to build on an 11-game hitting streak in this matchup. In his last 10 games he is hitting .389 with three doubles, four home runs, five walks and seven RBIs.
• Steven Kwan leads his team with a .378 on-base percentage, and has a club-best .438 slugging percentage. He has a batting average of .318.
• He is currently eighth in batting average, 25th in on-base percentage and 65th in slugging percentage among all qualified batters.
• Kyle Manzardo is hitting .223 with four doubles, two triples, 10 home runs and 18 walks.
• Carlos Santana is batting .215 with three doubles, four home runs and 22 walks.

Reds vs Guardians Head to Head

• 5/17/2025: 4-1 CIN (Favorite: Guardians, Spread: -1.5, Total: 10, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/16/2025: 5-4 CIN (Favorite: Guardians, Spread: -1.5, Total: 9.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/25/2024: 5-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 9/24/2024: 6-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 6/12/2024: 4-2 CIN (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/11/2024: 5-3 CLE (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/27/2023: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 9/26/2023: 11-7 CIN (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 8/16/2023: 7-2 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 8/15/2023: 3-0 CLE (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -120, Underdog Moneyline: +102)

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