Reds vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 29

Odds updated as of 7:14 a.m.

The MLB's Friday schedule includes the Cincinnati Reds taking on the St. Louis Cardinals.

All the information you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Reds vs Cardinals Game Info

• Cincinnati Reds (68-66) vs. St. Louis Cardinals (66-69)
• Date: Friday, August 29, 2025
• Time: 6:40 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: FDSOH and FDSMW

Reds vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CIN: (-122) | STL: (+104)
• Spread: CIN: +1.5 (-205) | STL: -1.5 (+168)
• Total: 9 -- Over: (-100) | Under: (-122)

Reds vs Cardinals Probable Starting Pitchers

Probable Pitchers: Zack Littell (Reds) - 9-8, 3.62 ERA vs Matthew Liberatore (Cardinals) - 6-11, 4.27 ERA

The Reds will give the nod to Zack Littell (9-8) versus the Cardinals and Matthew Liberatore (6-11). Littell's team is 13-13-0 against the spread this season in his starts. Littell's team has been victorious in 55.6% of the games he's started as the moneyline favorite with a record of 5-4. The Cardinals are 11-11-0 ATS in Liberatore's 22 starts with a set spread. The Cardinals have a 7-2 record in Liberatore's nine starts this season when they were the moneyline underdog.

Reds vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Reds win (54.2%)

Reds vs Cardinals Moneyline

• The moneyline numbers for Reds vs. Cardinals reveal Cincinnati as the favorite (-122) and St. Louis as the underdog (+104) on the road.

Reds vs Cardinals Spread

• The Cardinals are 1.5-run favorites against the spread for this matchup with the Reds. The Cardinals are +168 to cover, while the Reds are -205 to cover as a 1.5-run underdog on the runline.

Reds vs Cardinals Over/Under

• The over/under for Reds-Cardinals on Aug. 29 is 9. The over is -100, and the under is -122.

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Reds vs Cardinals Betting Trends

• The Reds have been chosen as favorites in 52 games this year and have walked away with the win 28 times (53.8%) in those games.
• This season Cincinnati has come away with a win 19 times in 35 chances when named as a favorite of at least -122 on the moneyline.
• The Reds' games have gone over the total in 49 of their 127 opportunities.
• The Reds are 67-60-0 against the spread in their 127 games with a line set by sportsbooks this season.
• The Cardinals have put together a 33-36 record in games they were the underdog on the moneyline (winning 47.8% of those games).
• St. Louis has an 18-26 record (winning 40.9% of its games) when playing as a moneyline underdog of +104 or longer.
• The Cardinals have played in 129 games with an over/under set, and have combined with opponents to go over the total 67 times (67-57-5).
• The Cardinals have a 65-64-0 record ATS this season.

Reds Player Leaders

• Elly De La Cruz leads Cincinnati with 142 hits and a team-best slugging percentage of .450. He's batting .272 with an on-base percentage of .343.
• Among all qualified hitters in baseball, he is 40th in batting average, 52nd in on-base percentage, and 63rd in slugging.
• De La Cruz has recorded at least one hit in two straight games. In his last five games he is hitting .227 with a double.
• TJ Friedl leads Cincinnati with an OBP of .364 this season while batting .266 with 62 walks and 70 runs scored. He's slugging .376.
• His batting average ranks 56th among qualified players, his on-base percentage 18th, and his slugging percentage 135th.
• Friedl has picked up a hit in three straight games. In his last five games he is hitting .238 with two walks and an RBI.
• Spencer Steer is batting .235 with a .396 slugging percentage and 62 RBI this year.
• Austin Hays has 11 home runs, 53 RBI and a batting average of .266 this season.

Cardinals Player Leaders

• Alec Burleson has accumulated a slugging percentage of .451 and has 123 hits, both team-best marks for the Cardinals. He's batting .286 and with an on-base percentage of .337.
• Including all qualifying hitters, he ranks 19th in batting average, while his on-base percentage ranks 62nd and he is 61st in slugging.
• Willson Contreras is hitting .255 with 30 doubles, 19 home runs and 40 walks. He's slugging .448 with an on-base percentage of .340.
• He is currently 88th in batting average, 55th in on-base percentage and 68th in slugging percentage among all qualified batters.
• Masyn Winn has 26 doubles, nine home runs and 32 walks while batting .254.
• Lars Nootbaar has 21 doubles, 13 home runs and 54 walks while batting .238.

Reds vs Cardinals Head to Head

• 6/22/2025: 4-1 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/21/2025: 6-5 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 6/20/2025: 6-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/1/2025: 9-1 CIN (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/30/2025: 9-1 STL (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/30/2025: 6-0 STL (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 4/28/2025: 3-1 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 9/12/2024: 6-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 9/11/2024: 2-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 9/10/2024: 3-0 CIN (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)

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